USP7

Gene Symbol	USP7
Entrez Gene	7874
Alt Symbol	HAUSP, TEF1
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 7 (herpes virus-associated)
Other Description	Herpes virus-associated ubiquitin-specific protease|deubiquitinating enzyme 7|herpesvirus-associated ubiquitin-specific protease|ubiquitin carboxyl-terminal hydrolase 7|ubiquitin specific protease 7 (herpes virus-associated)|ubiquitin thioesterase 7|ubiquitin-specific-processing protease 7
Swissprots	Q93009 B7Z815 H0Y3G8 A6NMY8
Accessions	CBJ21210 EAW85194 EAW85195 Q93009 AK302481 BAH13721 AK302771 BAH13801 AK302872 BAH13828 AK302912 BAH13841 AK316441 BAH14812 AY376241 AAQ82908 BC166690 AAI66690 Z72499 CAA96580 NM_001286457 NP_001273386 NM_001286458 NP_001273387 NM_003470 NP_003461
Function	Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interact
Subcellular Location	Nucleus {ECO:0000269|PubMed:23973222}. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
Tissue Specificity	Widely expressed. Overexpressed in prostate cancer. {ECO:0000269|PubMed:18716620}.
Top Pathways	Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HAUSP / USP7 full length protein - ab198464 from Abcam Category Protein Prices $608.00 Sizes 100 µg Source Baculovirus infected sf9 cells Species Human

Active human HAUSP / USP7 protein fragment - ab188713 from Abcam Category Protein Prices $243.00 Sizes 50 µg Source E. coli Species Human

USP7 / HAUSP Antibody Blocking Peptide - LS-E4403 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP7 / HAUSP Antibody Blocking Peptide - LS-E21602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP7 / HAUSP Antibody Blocking Peptide - LS-E6882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP7 Protein - H00007874-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP7 Peptide - NBP1-96763 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

USP7 Peptide - P0927 from Novus Biologicals Category Peptide Species Human

USP7-Antibody-Center-Blocking-Peptide - BP16712c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP7-HAUSP-Antibody-C-term-Blocking-peptide - BP2136b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-USP7, CF - E-519-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains an N-terminal 6-His tag

Recombinant Human His6-USP7 Catalytic Domain, CF - E-518B-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal Met-Gly-Ser-Ser and 6-His tag

Human USP7 His GST tag protein - orb83703 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Insect Species Human

USP7 / HAUSP - H00007874-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP7 / HAUSP - H00007874-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP7 / HAUSP Control Peptide - AP09237CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

USP7, Active Human Recombinant Protein - GWB-PS99CD from Genway Biotech Category Protein Prices $566.00 Sizes 100 µg Species Human

Recombinant Human USP7, His & GST tagged - USP7-924H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human USP7, His & GST tagged - USP7-925H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human USP7, None tagged - USP7-926H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human USP7, His-tagged - USP7-29182TH from Creative Biomart Category Protein Source E. coli

Recombinant Human USP7, His-tagged - USP7-160H from Creative Biomart Category Protein Source Insect Cells Species Human

Ubiquitin Carboxyl-terminal Hydrolase 7 - CBCRY35 from Creative Biomart Category Protein Source E.coli

USP7 / HAUSP - PN201697 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Insect cells Species Human

Recombinant Ubiquitin Specific Peptidase 7 (USP7) - RPC255Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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