USP7

Gene Symbol USP7
Entrez Gene 7874
Alt Symbol HAUSP, TEF1
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 7 (herpes virus-associated)
Other Description Herpes virus-associated ubiquitin-specific protease|deubiquitinating enzyme 7|herpesvirus-associated ubiquitin-specific protease|ubiquitin carboxyl-terminal hydrolase 7|ubiquitin specific protease 7 (herpes virus-associated)|ubiquitin thioesterase 7|ubiquitin-specific-processing protease 7
Swissprots Q93009 B7Z815 H0Y3G8 A6NMY8
Accessions CBJ21210 EAW85194 EAW85195 Q93009 AK302481 BAH13721 AK302771 BAH13801 AK302872 BAH13828 AK302912 BAH13841 AK316441 BAH14812 AY376241 AAQ82908 BC166690 AAI66690 Z72499 CAA96580 NM_001286457 NP_001273386 NM_001286458 NP_001273387 NM_003470 NP_003461
Function Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interact
Subcellular Location Nucleus {ECO:0000269|PubMed:23973222}. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
Tissue Specificity Widely expressed. Overexpressed in prostate cancer. {ECO:0000269|PubMed:18716620}.
Top Pathways Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection

HAUSP CRISPR/Cas9 KO Plasmid (h) - sc-402013 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP HDR Plasmid (h) - sc-402013-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP Double Nickase Plasmid (h) - sc-402013-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP Double Nickase Plasmid (h2) - sc-402013-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP CRISPR Activation Plasmid (h) - sc-402013-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP CRISPR Activation Plasmid (h2) - sc-402013-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP Lentiviral Activation Particles (h) - sc-402013-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP Lentiviral Activation Particles (h2) - sc-402013-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP siRNA (h) - sc-41521 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HAUSP shRNA Plasmid (h) - sc-41521-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HAUSP shRNA (h) Lentiviral Particles - sc-41521-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU131171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2158 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2158 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12793 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12793

USP7 siRNA (Human) - CRH5305 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP7 - MBS8206810 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HAUSP CRISPR/Cas9 KO Plasmid (h2) - sc-402013-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HAUSP HDR Plasmid (h2) - sc-402013-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human USP7 (NM_003470.2) - SHH441796 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human USP7(NM_003470.2) - SHL118938 from Creative biogene

Category siRNA
Species Reactivities Human

Human USP7 siRNA - orb265807 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP7 shRNA Plasmid (Human) - CHH5305 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USP7 miRNA 3'UTR clone - MiUTR1H-11074 from Creative biogene

Species Reactivities Human
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