USP7

Gene Symbol USP7
Entrez Gene 7874
Alt Symbol HAUSP, TEF1
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 7 (herpes virus-associated)
Other Description Herpes virus-associated ubiquitin-specific protease|deubiquitinating enzyme 7|herpesvirus-associated ubiquitin-specific protease|ubiquitin carboxyl-terminal hydrolase 7|ubiquitin specific protease 7 (herpes virus-associated)|ubiquitin thioesterase 7|ubiquitin-specific-processing protease 7
Swissprots Q93009 B7Z815 H0Y3G8 A6NMY8
Accessions CBJ21210 EAW85194 EAW85195 Q93009 AK302481 BAH13721 AK302771 BAH13801 AK302872 BAH13828 AK302912 BAH13841 AK316441 BAH14812 AY376241 AAQ82908 BC166690 AAI66690 Z72499 CAA96580 NM_001286457 NP_001273386 NM_001286458 NP_001273387 NM_003470 NP_003461
Function Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interact
Subcellular Location Nucleus {ECO:0000269|PubMed:23973222}. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
Tissue Specificity Widely expressed. Overexpressed in prostate cancer. {ECO:0000269|PubMed:18716620}.
Top Pathways Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection

HAUSP (D17C6) XP ® Rabbit mAb - 4833 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D17C6
Western blot analysis of extracts from various cell lines using HAUSP (D17C6) XP ® Rabbit mAb.

HAUSP Antibody - 3277 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF-7, NIH/3T3 and PC12 cells using HAUSP Antibody.

HAUSP (G-10) - sc-376912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAUSP (G-10): sc-376912. Western blot analysis of HAUSP expression in non-transfected 293T: sc-117752 (A), mouse HAUSP transfected 293T: sc-178723 (B) and Jurkat (C) whole cell lysates.

HAUSP (F-2) - sc-137001 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAUSP (F-2): sc-137001. Western blot analysis of HAUSP expression in HeLa (A) and Jurkat (B) whole cell lysates.

HAUSP (G-12) - sc-377147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAUSP (G-12): sc-377147. Western blot analysis of HAUSP expression in non-transfected 293T: sc-117752 (A), mouse HAUSP transfected 293T: sc-178723 (B) and HeLa (C) whole cell lysates.

HAUSP (C-2) - sc-133204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAUSP (C-2): sc-133204. Western blot analysis of HAUSP expression in A-431 whole cell lysate.

HAUSP (H-12) - sc-137008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HAUSP (H-12): sc-137008. Western blot analysis of HAUSP expression in HeLa (A) and A-431 (B) whole cell lysates.

HAUSP (H-200) - sc-30164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HAUSP (H-200): sc-30164. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

HAUSP (N-18) - sc-22848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HAUSP (N-18): sc-22848. Western blot analysis of HAUSP expression in HeLa (A), A-431 (B), K-562 (C) and Jurkat (D) whole cell lysates.

Anti-HAUSP / USP7 antibody - ab4080 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HAUSP / USP7 antibody - ab183659 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HAUSP / USP7 antibody (ab183659) at 1/5000 dilutionLane 1 : NIH-3T3 whole cell lysateLane 2 : JC whole cell lysateLane 3 : BCL-1 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HAUSP / USP7 antibody - ab157132 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
All lanes : Anti-HAUSP / USP7 antibody (ab157132) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-HAUSP / USP7 antibody - ab101648 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HAUSP / USP7 antibody (ab101648) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 5 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 6 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 7 : PC3 (Human prostate cancer cell line) Whole Cell Lysate (ab3954)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HAUSP / USP7 antibody - ab84098 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human HAUSP / USP7 by Immunohistochemistry.Sample: FFPE section of Human stomach adenocarcinoma.Antibody: ab84098 used at a dilution of 1/500.Detection: DAB.

Anti-HAUSP / USP7 antibody [3D3] - ab119364 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D3
All lanes : Anti-HAUSP / USP7 antibody [3D3] (ab119364) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY HAUSP/USP7 cDNALysates/proteins at 5 µg per lane.

Anti-HAUSP / USP7 antibody [3E4-D10-E8] - ab151262 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E4-D10-E8
developed using the ECL technique

Anti-HAUSP / USP7 antibody [EPR4253] - ab108931 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4253
All lanes : Anti-HAUSP / USP7 antibody [EPR4253] (ab108931) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : HeLa cell lysateLane 3 : A431 cell lysateLane 4 : MCF7 cell lysateLane 5 : C6 cell lysateLane 6 : RAW 264.7 cell lysateLysates/proteins at 10 µg per lane.

Anti-HAUSP / USP7 antibody [EPR4254] - ab109109 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4254
All lanes : Anti-HAUSP / USP7 antibody [EPR4254] (ab109109) at 1/1000 dilutionLane 1 : T47-D cell lysateLane 2 : Hela cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-HAUSP / USP7 antibody - C-terminal - ab71746 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HAUSP / USP7 antibody - C-terminal (ab71746) at 1/100 dilution + T47D cell lysate at 12.5 µg

Anti-HAUSP / USP7 Antibody (aa1-50) - LS-C286293 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Mouse USP7 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-USP7 used at a dilution of 1:100. Detection: DAB.

Anti-USP7 / HAUSP Antibody (clone 3F7) - LS-C173418 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F7
IHC of paraffin-embedded Human endometrium tissue using anti-USP7 mouse monoclonal antibody.

Anti-USP7 / HAUSP Antibody (aa1-50) IHC-plus™ - LS-B12198 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-USP7 / HAUSP Antibody (clone 3D5) - LS-C337584 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D5
IHC of paraffin-embedded Human tonsil using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-USP7 / HAUSP Antibody (aa1050-1100) IHC-plus™ - LS-B7235 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-USP7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7235 concentration 10 ug/ml.

Anti-USP7 / HAUSP Antibody (C-Terminus) IHC-plus™ - LS-B12199 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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