| Gene Symbol |
STK36
|
| Entrez Gene |
27148
|
| Alt Symbol |
FU
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine kinase 36
|
| Other Description |
fused homolog|serine/threonine-protein kinase 36
|
| Swissprots |
Q9ULE2 Q9UF35 B7WPM3 Q8TC32 Q9NRP7 Q9H9N9
|
| Accessions |
CAC16640 EAW70647 EAW70648 EAW70649 EAW70650 Q9NRP7 AA524236 AA992176 AB033104 BAA86592 AF200815 AAF97028 AK022692 BAB14184 AL133630 CAB63754 BC026158 AAH26158 DB062910 DQ891739 ABM82665 DQ894916 ABM85842 XM_005246464 XP_005246521 XM_011510959 XP_011509261 XM_011510960 XP_011509262 XM_011510961 XP_011509263 XR_922904 NM_001243313 NP_001230242 NM_015690 NP_056505
|
| Function |
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. {ECO:0000269|PubMed:10806483}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10806483}. Nucleus {ECO:0000269|PubMed:10806483}. Note=Low levels also present in the nucleus.
|
| Tissue Specificity |
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells. {ECO:0000269|PubMed:10806483}.
|
| Top Pathways |
Hedgehog signaling pathway, Basal cell carcinoma
|
