| Gene Symbol |
SLC22A5
|
| Entrez Gene |
6584
|
| Alt Symbol |
CDSP, OCTN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic cation/carnitine transporter), member 5
|
| Other Description |
high-affinity sodium dependent carnitine cotransporter|organic cation/carnitine transporter 2|solute carrier family 22 member 5
|
| Swissprots |
Q6ZQZ8 D3DQ87 O76082 Q96EH6 B2R844 A2Q0V1
|
| Accessions |
BAA36712 CAX30725 EAW62337 EAW62338 EAW62339 O76082 AB015050 BAA29023 AB209484 BAD92721 AB291606 BAF45812 AF057164 AAC24828 AK128610 BAC87527 AK313230 BAG36041 AY429569 BC012325 AAH12325 BM693015 DA186237 DA567722 DQ893671 ABM84597 DQ895818 ABM86744 XM_005272055 XP_005272112 XM_011543590 XP_011541892 XR_427718 XR_948290 XR_948291 NM_001308122 NP_001295051 NM_003060 NP_003051
|
| Function |
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. {ECO:0000269|PubMed:10454528}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:10679939}; Multi-pass membrane protein {ECO:0000269|PubMed:10679939}.
|
| Tissue Specificity |
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. {ECO:0000269|PubMed:10454528}.
|
| Top Pathways |
Choline metabolism in cancer
|
