SLC22A5

Gene Symbol SLC22A5
Entrez Gene 6584
Alt Symbol CDSP, OCTN2
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation/carnitine transporter), member 5
Other Description high-affinity sodium dependent carnitine cotransporter|organic cation/carnitine transporter 2|solute carrier family 22 member 5
Swissprots Q6ZQZ8 D3DQ87 O76082 Q96EH6 B2R844 A2Q0V1
Accessions BAA36712 CAX30725 EAW62337 EAW62338 EAW62339 O76082 AB015050 BAA29023 AB209484 BAD92721 AB291606 BAF45812 AF057164 AAC24828 AK128610 BAC87527 AK313230 BAG36041 AY429569 BC012325 AAH12325 BM693015 DA186237 DA567722 DQ893671 ABM84597 DQ895818 ABM86744 XM_005272055 XP_005272112 XM_011543590 XP_011541892 XR_427718 XR_948290 XR_948291 NM_001308122 NP_001295051 NM_003060 NP_003051
Function Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. {ECO:0000269|PubMed:10454528}.
Subcellular Location Membrane {ECO:0000269|PubMed:10679939}; Multi-pass membrane protein {ECO:0000269|PubMed:10679939}.
Tissue Specificity Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. {ECO:0000269|PubMed:10454528}.
Top Pathways Choline metabolism in cancer

OCTN2 CRISPR/Cas9 KO Plasmid (h) - sc-404574 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 HDR Plasmid (h) - sc-404574-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 Double Nickase Plasmid (h) - sc-404574-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 Double Nickase Plasmid (h2) - sc-404574-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 CRISPR Activation Plasmid (h) - sc-404574-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 CRISPR Activation Plasmid (h2) - sc-404574-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 Lentiviral Activation Particles (h) - sc-404574-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 Lentiviral Activation Particles (h2) - sc-404574-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN2 siRNA (h) - sc-42560 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN2 shRNA Plasmid (h) - sc-42560-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN2 shRNA (h) Lentiviral Particles - sc-42560-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN2/SLC22A5 RNAi - H00006584-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU017231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19469 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19469 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SLC22A5 siRNA (Human) - CRH4472 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A5 - MBS8212630 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A5 (NM_003060.3) - SHH409216 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SLC22A5(NM_003060.3) - SHL001630 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC22A5 siRNA - orb264974 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A5 shRNA Plasmid (Human) - CHH4472 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A5 miRNA 3'UTR clone - MiUTR1H-09464 from Creative biogene

Species Reactivities Human
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