| Gene Symbol | SPIB |
|---|---|
| Entrez Gene | 6689 |
| Alt Symbol | SPI-B |
| Species | Human |
| Gene Type | protein-coding |
| Description | Spi-B transcription factor (Spi-1/PU.1 related) |
| Other Description | transcription factor Spi-B |
| Swissprots | Q15359 A8K9C9 B4DUG6 Q01892 |
| Accessions | EAW71858 EAW71859 EAW71860 EAW71861 EAW71862 EAW71863 EAW71864 Q01892 AK025419 AK225225 AK225720 AK292644 BAF85333 AK300639 BAG62328 BC007921 AAH07921 BQ064401 DA957263 EU446656 ABZ92185 GD140573 X66079 CAA46878 X96998 CAA65726 NM_001243998 NP_001230927 NM_001243999 NP_001230928 NM_001244000 NP_001230929 NM_003121 NP_003112 |
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:12393575, ECO:0000269|PubMed:1406622, ECO:0000269|PubMed:15583020}. |
| Subcellular Location | Isoform 1: Nucleus. |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269|PubMed:11841448, ECO:0000269|PubMed:12393575}. |