SPIB

Gene Symbol	SPIB
Entrez Gene	6689
Alt Symbol	SPI-B
Species	Human
Gene Type	protein-coding
Description	Spi-B transcription factor (Spi-1/PU.1 related)
Other Description	transcription factor Spi-B
Swissprots	Q15359 A8K9C9 B4DUG6 Q01892
Accessions	EAW71858 EAW71859 EAW71860 EAW71861 EAW71862 EAW71863 EAW71864 Q01892 AK025419 AK225225 AK225720 AK292644 BAF85333 AK300639 BAG62328 BC007921 AAH07921 BQ064401 DA957263 EU446656 ABZ92185 GD140573 X66079 CAA46878 X96998 CAA65726 NM_001243998 NP_001230927 NM_001243999 NP_001230928 NM_001244000 NP_001230929 NM_003121 NP_003112
Function	Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:12393575, ECO:0000269|PubMed:1406622, ECO:0000269|PubMed:15583020}.
Subcellular Location	Isoform 1: Nucleus.
Tissue Specificity	Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269|PubMed:11841448, ECO:0000269|PubMed:12393575}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPIB full length protein - ab114705 from Abcam Category Protein Source Wheat germ Species Human

SPIB Antibody Blocking Peptide - LS-E6653 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPIB Antibody Blocking Peptide - LS-E10979 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Spi-B Protein - H00006689-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SPIB-AntibodyC-term-Blocking-peptide - BP19462b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPIB - H00006689-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SPIB - H00006689-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SPIB Peptide - 8157P from ProSci Category Peptide Species Human

SPIB fusion protein - ag8404 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SPIB - SPIB-811H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Transcription factor Spi-B(SPIB) - CSB-YP022568HU CSB-EP022568HU CSB-BP022568HU CSB-MP022568HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SPIB Protein - abx164361 from Abbexa Category Protein Species Human, Mouse, Rat

Spi-B Recombinant Protein Antigen - NBP1-80729PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SPIB Peptide, Human - M34GP15045H from Creative Peptides Category Peptide Source Synthetic. Species Human

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