SPIB

Gene Symbol SPIB
Entrez Gene 6689
Alt Symbol SPI-B
Species Human
Gene Type protein-coding
Description Spi-B transcription factor (Spi-1/PU.1 related)
Other Description transcription factor Spi-B
Swissprots Q15359 A8K9C9 B4DUG6 Q01892
Accessions EAW71858 EAW71859 EAW71860 EAW71861 EAW71862 EAW71863 EAW71864 Q01892 AK025419 AK225225 AK225720 AK292644 BAF85333 AK300639 BAG62328 BC007921 AAH07921 BQ064401 DA957263 EU446656 ABZ92185 GD140573 X66079 CAA46878 X96998 CAA65726 NM_001243998 NP_001230927 NM_001243999 NP_001230928 NM_001244000 NP_001230929 NM_003121 NP_003112
Function Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:12393575, ECO:0000269|PubMed:1406622, ECO:0000269|PubMed:15583020}.
Subcellular Location Isoform 1: Nucleus.
Tissue Specificity Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269|PubMed:11841448, ECO:0000269|PubMed:12393575}.

Spi-B CRISPR/Cas9 KO Plasmid (h) - sc-402613 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B HDR Plasmid (h) - sc-402613-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B Double Nickase Plasmid (h) - sc-402613-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B Double Nickase Plasmid (h2) - sc-402613-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B CRISPR Activation Plasmid (h) - sc-402613-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B CRISPR Activation Plasmid (h2) - sc-402613-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B Lentiviral Activation Particles (h) - sc-402613-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B Lentiviral Activation Particles (h2) - sc-402613-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spi-B siRNA (h) - sc-37869 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spi-B shRNA Plasmid (h) - sc-37869-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spi-B shRNA (h) Lentiviral Particles - sc-37869-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spi-B RNAi - H00006689-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU030231 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20470 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20470 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05891 from Sigma-Aldrich

Category miRNA

SPIB siRNA (Human) - CRH4559 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPIB - MBS8233904 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPIB (NM_003121.4) - SHH416648 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPIB siRNA - orb265061 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPIB shRNA Plasmid (Human) - CHH4559 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPIB miRNA 3'UTR clone - MiUTR3H-08724 from Creative biogene

Species Reactivities Human
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