SPIB

Gene Symbol	SPIB
Entrez Gene	6689
Alt Symbol	SPI-B
Species	Human
Gene Type	protein-coding
Description	Spi-B transcription factor (Spi-1/PU.1 related)
Other Description	transcription factor Spi-B
Swissprots	Q15359 A8K9C9 B4DUG6 Q01892
Accessions	EAW71858 EAW71859 EAW71860 EAW71861 EAW71862 EAW71863 EAW71864 Q01892 AK025419 AK225225 AK225720 AK292644 BAF85333 AK300639 BAG62328 BC007921 AAH07921 BQ064401 DA957263 EU446656 ABZ92185 GD140573 X66079 CAA46878 X96998 CAA65726 NM_001243998 NP_001230927 NM_001243999 NP_001230928 NM_001244000 NP_001230929 NM_003121 NP_003112
Function	Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269\|PubMed:10196196, ECO:0000269\|PubMed:12393575, ECO:0000269\|PubMed:1406622, ECO:0000269\|PubMed:15583020}.
Subcellular Location	Isoform 1: Nucleus.
Tissue Specificity	Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269\|PubMed:11841448, ECO:0000269\|PubMed:12393575}.

Spi-B (D3C5E) Rabbit mAb - 14323 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (50 immunoprecipitations)
Host	Rabbit
Clonality	Monoclonal
Clone	D3C5E

Immunoprecipitation of Spi-B from Raji cell extracts using Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (lane 2) or Spi-B (D3C5E) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using Spi-B (D4V9S) Rabbit mAb #14337.

Spi-B (D4V9S) Rabbit mAb - 14337 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D4V9S

Western blot analysis of extracts from various cell lines using Spi-B (D4V9S) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Spi-B (N-16) - sc-5944 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Spi-B (N-16): sc-5944. Western blot analysis of Spi-B expression in WEHI-231 (A), NAMALWA (B), CTLL-2 (C), NIH/3T3 (D) and MCP-5 (E) whole cell lysates.

Spi-B (L-15) - sc-5945 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Spi-B (L-15): sc-5945. Western blot analysis of Spi-B expression in WEHI-231 nuclear extract (A) and Jurkat (B), Raji (C) and K-562 (D) whole cell lysates.

Spi-B (C-16) - sc-5947 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Spi-B (C-16): sc-5947. Western blot analysis of Spi-B expression in WEHI-231 (A) and CTLL-2 (B) whole cell lysates.

Spi-B (H-170) - sc-367803 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB antibody - ab42436 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SPIB antibody (ab42436) at 0.25 µg/mlLane 1 : MW markerLane 2 : Daudi cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SPIB antibody [4G5] - ab135238 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

All lanes : Anti-SPIB antibody [4G5] (ab135238) at 1/500 dilutionLane 1 : A549 cell lysateLane 2 : PC3 cell lysateLane 3 : NIH 3T3 cell lysate

Anti-SPIB antibody - C-terminal - ab174226 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB antibody - C-terminal (ab174226) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-SPIB Antibody (aa216-245, AP) - LS-C270196 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245, APC) - LS-C270197 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245, Biotin) - LS-C270198 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245, Azide-free, HRP) - LS-C270199 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245, FITC) - LS-C270200 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245, PE) - LS-C270201 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (aa216-245) - LS-C325328 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (C-Terminus) - LS-C336282 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (C-Terminus) - LS-C30130 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPIB Antibody (C-Terminus) - LS-C110255 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

SPIB antibody LS-C110255 Western blot of NCI-H226 cell lysate.

Anti-SPIB Antibody (aa110-160) - LS-C148472 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Spi-B in human spleen lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148472 at 1.0 ug/ml.

Anti-SPIB Antibody (aa216-245) - LS-C156118 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SPIB Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The SPIB antibody detected the SPIB protein (arrow).

Anti-SPIB Antibody (clone 4G5) - LS-C169118 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

IHC of paraffin-embedded ovarian cancer tissues using SPIB mouse monoclonal antibody with DAB staining.

Spi-B Antibody (4G5) - NBP2-37458 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4G5

Western Blot: Spi-B Antibody (4G5) [NBP2-37458] - Western blot analysis using SPIB mouse mAb against A549 (1), PC-3 (2), and NIH3T3 (3) cell lysate.

Spi-B Antibody - NBP1-70345 from Novus Biologicals

Prices	$99.00, $279.00
Sizes	25 µg, 100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: SPIB Antibody [NBP1-70345] - Analysis of Spi-B in human Daudi lysate in the 1) absence and 2) presence of immunizing peptide and 3) on mouse RAW lysate using Spi-B polyclonal antibody at 4 ug/ml.

Spi-B Antibody - NBP2-24625 from Novus Biologicals

Prices	$259.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: SPIB Antibody [NBP2-24625] - Analysis of Spi-B in human spleen lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. 0 ug/ml.

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