| Gene Symbol |
UBE2I
|
| Entrez Gene |
7329
|
| Alt Symbol |
C358B7.1, P18, UBC9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2I
|
| Other Description |
SUMO-1-protein ligase|SUMO-conjugating enzyme UBC9|SUMO-protein ligase|ubiquitin carrier protein 9|ubiquitin carrier protein I|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)|ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)|ubiquitin-conjugating enzyme UbcE2A|ubiquitin-like protein SUMO-1 conjugating enzyme|ubiquitin-protein ligase E2I|ubiquitin-protein ligase I
|
| Swissprots |
D3DU69 P63279 Q59GX1
|
| Accessions |
AAK61274 CBJ93564 CBK25700 EAW85673 EAW85674 EAW85675 EAW85676 EAW85677 EAW85678 EAW85679 P63279 AB208988 BAD92225 AJ002385 CAA05359 AK024172 AK093616 AK291118 BAF83807 AL833737 BC000427 AAH00427 BC000744 BC004429 AAH04429 BC004437 BC014997 BC051289 AAH51289 BC064492 BC069256 BE262845 BF315618 BG530957 BI523501 BI793063 BQ230918 BQ358820 BT006932 AAP35578 BT007010 AAP35656 BU146357 BU543455 CD249028 CX788607 D45050 BAA08091 DQ891373 ABM82299 DQ894552 ABM85478 U29092 AAC51361 U31882 AAC50603 U31933 AAB02181 U38785 AAB09410 U45328 AAA86662 U66818 AAC50715 U66867 AAC50716 X96427 CAA65287 XM_005255540 XP_005255597 XM_005255541 XP_005255598 XM_011522644 XP_011520946 XM_011522645 XP_011520947 NM_003345 NP_003336 NM_194259 NP_919235 NM_194260 NP_919236 NM_194261 NP_919237
|
| Function |
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:8668529}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269|PubMed:8610150}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, RNA transport, MicroRNAs in cancer
|