UBE2I

Gene Symbol	UBE2I
Entrez Gene	7329
Alt Symbol	C358B7.1, P18, UBC9
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2I
Other Description	SUMO-1-protein ligase|SUMO-conjugating enzyme UBC9|SUMO-protein ligase|ubiquitin carrier protein 9|ubiquitin carrier protein I|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)|ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)|ubiquitin-conjugating enzyme UbcE2A|ubiquitin-like protein SUMO-1 conjugating enzyme|ubiquitin-protein ligase E2I|ubiquitin-protein ligase I
Swissprots	D3DU69 P63279 Q59GX1
Accessions	AAK61274 CBJ93564 CBK25700 EAW85673 EAW85674 EAW85675 EAW85676 EAW85677 EAW85678 EAW85679 P63279 AB208988 BAD92225 AJ002385 CAA05359 AK024172 AK093616 AK291118 BAF83807 AL833737 BC000427 AAH00427 BC000744 BC004429 AAH04429 BC004437 BC014997 BC051289 AAH51289 BC064492 BC069256 BE262845 BF315618 BG530957 BI523501 BI793063 BQ230918 BQ358820 BT006932 AAP35578 BT007010 AAP35656 BU146357 BU543455 CD249028 CX788607 D45050 BAA08091 DQ891373 ABM82299 DQ894552 ABM85478 U29092 AAC51361 U31882 AAC50603 U31933 AAB02181 U38785 AAB09410 U45328 AAA86662 U66818 AAC50715 U66867 AAC50716 X96427 CAA65287 XM_005255540 XP_005255597 XM_005255541 XP_005255598 XM_011522644 XP_011520946 XM_011522645 XP_011520947 NM_003345 NP_003336 NM_194259 NP_919235 NM_194260 NP_919236 NM_194261 NP_919237
Function	Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:8668529}.
Subcellular Location	Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269|PubMed:8610150}.
Top Pathways	Ubiquitin mediated proteolysis, RNA transport, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2I / UBC9 full length protein - ab151910 from Abcam Category Protein Source E. coli Species Human

Human UBE2I / UBC9 full length protein - ab173073 from Abcam Category Protein Source E. coli Species Human

Human UBE2I / UBC9 full length protein - ab51167 from Abcam Category Protein Source E. coli Species Human

Human UBE2I / UBC9 full length protein - ab157071 from Abcam Category Protein Source E. coli Species Human

Human UBE2I / UBC9 peptide - ab30700 from Abcam Category Peptide

Human UBE2I / UBC9 peptide - ab30701 from Abcam Category Peptide

Human UBE2I / UBC9 peptide - ab45493 from Abcam Category Peptide Species Human

UBE2I / UBC9 full length protein - ab3803 from Abcam Category Protein Source E. coli

UBE2I / UBC9 protein (His tag) - ab127405 from Abcam Category Protein Source E. coli Species Human

UBE2I / UBC9 Antibody Blocking Peptide - LS-E374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2I / UBC9 Antibody Blocking Peptide - LS-E25472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2I / UBC9 Antibody Blocking Peptide - LS-E15650 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2I / UBC9 Antibody Blocking Peptide - LS-E15831 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBE2I/Ubc9 Protein - NBP2-35117 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 10 µg, 50 µg Source E. coli Species Human

Recombinant Human UBE2I/Ubc9 His (N-Term) Protein - NBP2-35094 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

UBE2I/Ubc9 Recombinant Protein - H00007329-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UBE2I/Ubc9 Protein - NBC1-18438 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

UBE2I/Ubc9 Peptide - P0180 from Novus Biologicals Category Peptide Species Human

UBC9-UBE2I-Antibody-N-term-Blocking-peptide - BP1064a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2I blocking peptide - GTX41193-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human UBE2I/Ubc9, CF - E2-645-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UBE2I/Ubc9, CF - E2-645-100 from R&D Systems Category Protein Source E. coli-derived,

Recombinant human SUMO-conjugating enzyme UBC9 (OPCA00335) - OPCA00335 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

UBE2I Protein His (OPPA00796) - OPPA00796 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

UBE2I Protein (OPPA00858) - OPPA00858 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

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