Kitl
| Gene Symbol | Kitl |
|---|---|
| Entrez Gene | 17311 |
| Alt Symbol | Clo, Con, Gb, Kitlg, Mgf, SCF, SF, SLF, Sl, blz, contrasted |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | kit ligand |
| Other Description | C-kit ligand|Steel factor|cloud gray|grizzle-belly|hematopoietic growth factor KL|mast cell growth factor|stem cell factor |
| Swissprots | Q3TNJ7 P97332 Q921N5 Q64222 Q62524 P20826 |
| Accessions | AAK71684 EDL21653 EDL21654 EDL21655 P20826 AK018777 BAB31402 AK041961 BAC31113 AK088655 AK134301 BAE22091 AK165233 BAE38091 AK165968 AK165969 BC011322 AAH11322 M57647 AAA39538 M59912 AAA39539 M59915 AAA40095 M64262 AAA39378 S40364 AAB22554 S40534 AAB22555 S40536 AAB22556 U44725 AAC52447 X68989 CAA48778 X95379 CAA64666 X95380 X95381 CAA64667 X99322 CAA67698 Y10287 CAA71329 XM_006513314 XP_006513377 XM_006513315 XP_006513378 NM_013598 NP_038626 |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Subcellular Location | Soluble KIT ligand: Secreted {ECO:0000250}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway |
Anti-SCF antibody - ab9753 from Abcam
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Anti-SCF antibody [2A8/32] - ab35936 from Abcam
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SCF/c-kit Ligand Antibody [Unconjugated] - AF-455-NA from Novus Biologicals
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SCF/c-kit Ligand Antibody - AB-455-NA from Novus Biologicals
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SCF/c-kit Ligand Antibody - AF6998 from Novus Biologicals
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SCF/c-kit Ligand Antibody [Biotin] - BAF455 from Novus Biologicals
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Anti-Stem Cell Factor antibody produced in goat - S6045 from Sigma-Aldrich
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STAT5A antibody - 70R-37488 from Fitzgerald
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STAT5A antibody (Tyr694) - 70R-37129 from Fitzgerald
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SCF antibody - 70R-12316 from Fitzgerald
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STAT5A antibody - 70R-35385 from Fitzgerald
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Stem Cell Factor Antibody - abx101394 from Abbexa
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KITLG / SCF antibody - AP26030PU-L from Acris Antibodies
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KITLG / SCF antibody - AP26030PU-N from Acris Antibodies
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KITLG / SCF antibody - PP018B1 from Acris Antibodies
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KITLG / SCF antibody - PP018B2 from Acris Antibodies
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KITLG / SCF antibody - PP018P1 from Acris Antibodies
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KITLG / SCF antibody - PP018P2 from Acris Antibodies
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KITLG / SCF antibody - PAB9539 from Acris Antibodies
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Rabbit Anti-SCF Antibody - 168-10912 from RayBiotech
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Rabbit Anti-Mouse SCF - DS-PB-01871 from RayBiotech
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Anti-Stem Cell Factor (SCF) - 20-2289 from ARP American Research Products
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SCF Antibody - XP-5266 from ProSci
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SCF Antibody (biotin) - XP-5266Bt from ProSci
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STEM CELL FACTOR, Polyclonal Antibody - MBS221279 from MyBioSource
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