| Gene Symbol | Kitl |
|---|---|
| Entrez Gene | 17311 |
| Alt Symbol | Clo, Con, Gb, Kitlg, Mgf, SCF, SF, SLF, Sl, blz, contrasted |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | kit ligand |
| Other Description | C-kit ligand|Steel factor|cloud gray|grizzle-belly|hematopoietic growth factor KL|mast cell growth factor|stem cell factor |
| Swissprots | Q3TNJ7 P97332 Q921N5 Q64222 Q62524 P20826 |
| Accessions | AAK71684 EDL21653 EDL21654 EDL21655 P20826 AK018777 BAB31402 AK041961 BAC31113 AK088655 AK134301 BAE22091 AK165233 BAE38091 AK165968 AK165969 BC011322 AAH11322 M57647 AAA39538 M59912 AAA39539 M59915 AAA40095 M64262 AAA39378 S40364 AAB22554 S40534 AAB22555 S40536 AAB22556 U44725 AAC52447 X68989 CAA48778 X95379 CAA64666 X95380 X95381 CAA64667 X99322 CAA67698 Y10287 CAA71329 XM_006513314 XP_006513377 XM_006513315 XP_006513378 NM_013598 NP_038626 |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Subcellular Location | Soluble KIT ligand: Secreted {ECO:0000250}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway |