Kitl

Gene Symbol	Kitl
Entrez Gene	17311
Alt Symbol	Clo, Con, Gb, Kitlg, Mgf, SCF, SF, SLF, Sl, blz, contrasted
Species	Mouse
Gene Type	protein-coding
Description	kit ligand
Other Description	C-kit ligand|Steel factor|cloud gray|grizzle-belly|hematopoietic growth factor KL|mast cell growth factor|stem cell factor
Swissprots	Q3TNJ7 P97332 Q921N5 Q64222 Q62524 P20826
Accessions	AAK71684 EDL21653 EDL21654 EDL21655 P20826 AK018777 BAB31402 AK041961 BAC31113 AK088655 AK134301 BAE22091 AK165233 BAE38091 AK165968 AK165969 BC011322 AAH11322 M57647 AAA39538 M59912 AAA39539 M59915 AAA40095 M64262 AAA39378 S40364 AAB22554 S40534 AAB22555 S40536 AAB22556 U44725 AAC52447 X68989 CAA48778 X95379 CAA64666 X95380 X95381 CAA64667 X99322 CAA67698 Y10287 CAA71329 XM_006513314 XP_006513377 XM_006513315 XP_006513378 NM_013598 NP_038626
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location	Soluble KIT ligand: Secreted {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse SCF/c-kit Ligand Protein - NBP2-35150 from Novus Biologicals Category Protein Prices $69.00, $169.00, $399.00, $2,669.00 Sizes 2 µg, 10 µg, 100 µg, 1 mg Source E. coli

Recombinant Mouse SCF/c-kit Ligand Protein - NBC1-18486 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg

SCF/c-kit Ligand Recombinant Protein - P4368 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Mouse

SCF/c-kit Ligand Protein - NBP1-99854 from Novus Biologicals Category Protein Prices $309.00 Sizes 10 µg Species Mouse

SCF/c-kit Ligand Protein - NBP1-99930 from Novus Biologicals Category Protein Species Mouse

SCF/c-kit Ligand Protein - NBP1-43191 from Novus Biologicals Category Protein Prices $269.00 Sizes 5 µg Species Mouse

SCF/c-kit Ligand Protein - NBP1-42893 from Novus Biologicals Category Protein Prices $879.00 Sizes 100 µg Species Mouse

SCF/c-kit Ligand Recombinant Protein - P4332 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Mouse

SCF recombinant protein - GTX65365 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Mouse

SCF recombinant protein - GTX65364 from GeneTex Category Protein Prices $529.00 Sizes 50 μg Source E. coli Species Mouse

SCF Recombinant Protein (Active) - GTX48296-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Mouse

SCF Recombinant Protein (Active) - GTX48297-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Mouse

SCF Protein (OPPA00540) - OPPA00540 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

STEM CELL FACTOR Recombinant Protein (OPSA11089) - OPSA11089 from Aviva Systems Biology Category Protein Prices $440.00 Sizes 10 µg Species Mouse

SCF protein - orb97827 from Biorbyt Category Protein Prices $451.00 Sizes 10 μg Source P20826 Species Mouse

Mouse SCF His tag protein - orb84418 from Biorbyt Category Protein Prices $162.00, $400.00, $731.00 Sizes 5 μg, 20 μg, 100 μg Source Insect Species Mouse

SCF protein (Mouse) - 30R-AS003x1 from Fitzgerald Category Protein Prices $1,500.00 Sizes 500 µg Source E.coli Species Mouse

SCF protein (Mouse) - 30R-2273 from Fitzgerald Category Protein Prices $1,295.00 Sizes 100 µg Source E.coli Species Mouse

SCF protein (Mouse) - 30R-AS003 from Fitzgerald Category Protein Prices $225.00 Sizes 10 µg Source E.coli Species Mouse

Mouse Stem Cell Factor Protein - abx069171 from Abbexa Category Protein Source E.coli Species Mouse

Mouse Stem Cell Factor Protein (Recombinant) - abx060822 from Abbexa Category Protein Source Mouse Species Mouse

KITLG / SCF (26-189) (recombinant) - AR50018PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

KITLG / SCF (26-189) (recombinant) - AR50018PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KITLG / SCF - PA030 from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source E. coli Species Mouse

KITLG / SCF - PA030X from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Mouse

Search more