Kitl

Gene Symbol	Kitl
Entrez Gene	17311
Alt Symbol	Clo, Con, Gb, Kitlg, Mgf, SCF, SF, SLF, Sl, blz, contrasted
Species	Mouse
Gene Type	protein-coding
Description	kit ligand
Other Description	C-kit ligand|Steel factor|cloud gray|grizzle-belly|hematopoietic growth factor KL|mast cell growth factor|stem cell factor
Swissprots	Q3TNJ7 P97332 Q921N5 Q64222 Q62524 P20826
Accessions	AAK71684 EDL21653 EDL21654 EDL21655 P20826 AK018777 BAB31402 AK041961 BAC31113 AK088655 AK134301 BAE22091 AK165233 BAE38091 AK165968 AK165969 BC011322 AAH11322 M57647 AAA39538 M59912 AAA39539 M59915 AAA40095 M64262 AAA39378 S40364 AAB22554 S40534 AAB22555 S40536 AAB22556 U44725 AAC52447 X68989 CAA48778 X95379 CAA64666 X95380 X95381 CAA64667 X99322 CAA67698 Y10287 CAA71329 XM_006513314 XP_006513377 XM_006513315 XP_006513378 NM_013598 NP_038626
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location	Soluble KIT ligand: Secreted {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SCF Mouse ELISA Kit - ab100740 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 5 pg/ml Range 2.74 pg/ml - 2000 pg/ml

Mouse SCF ELISA Kit - RAB0329 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

SCF ELISA Kit (Mouse) : 96 Wells (OKAG00099) - OKAG00099 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 23 pg/mL Range 23-2,000 pg/mL

Kit ligand (KITLG), Mouse, ELISA Kit - E03K0089 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Kit ligand, Kitlg, Mouse, ELISA Kit - E0120m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 0.078-5 ng/ml

Stem Cell Factor (SCF), Mouse, ELISA Kit - SEA120Mu from ARP American Research Products Category ELISA Kit Prices $448.00 Sizes 96 t Sensitivity 6.8pg/mL Range 15.6-1,000pg/mL

Stem Cell Factor, Mouse, ELISA Kit - E03S0011 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Range 1.0-25ng/ml

Stem cell factor/mast cell growth factor, SCF/MGF, Mouse, ELISA Kit - CSB-E04719m from ARP American Research Products Category ELISA Kit Prices $465.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Stem Cell Factor/Mast Cell Growth Factor, SCF/MGF, Mouse, ELISA Kit - YHB1257Mo from ARP American Research Products Category ELISA Kit

Kitl (Mouse) ELISA Kit - KA1812 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Kitl (Mouse) ELISA Kit - KA1844 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Mouse SCF ELISA - ELM-SCF from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 5 pg/ml Range 5 pg/ml - 2000 pg/ml

Mouse SCF ELISA Kit - MS0018 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse SCF ELISA Kit - EK000110-EK0509 from Syd Labs Category ELISA Kit Prices $456.00, $1,596.00 Sizes 1 plate, 96t/plate, 4 plates, 96t/plate Sensitivity < 2 pg/ml Range 31.2ug/ml-2000ug/ml

SCF (Murine) OmniKine™ ELISA Kit - OK-0198 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 23-2000 pg/ml

Mouse SCF ELISA Kit - GWB-WKBX16 from Genway Biotech Category ELISA Kit Prices $599.00 Sizes 1x96 well plate Range 31.2pg/ml-2000pg/ml. Test has a sensitivity of < 10 pg/ml

Mouse SCF ELISA Kit - GWB-SKR099 from Genway Biotech Category ELISA Kit Prices $520.00 Sizes 96 tests Sensitivity 23 pg/mL Range 23-2000 pg/ml

Mouse SCF ELISA Kit - DEIA8412 from Creative Diagnostics Category ELISA Kit Range 62.5pg/mL-4000pg/mL

Mouse SCF ELISA kit - DEIA5763 from Creative Diagnostics Category ELISA Kit Sensitivity 5 pg/mL

SCF Mouse ELISA Kit - DEIA1605 from Creative Diagnostics Category ELISA Kit Sensitivity 5 pg/mL Range 2.74 pg/mL - 2000 pg/mL

Mouse SCF(Stem Cell Factor) ELISA Kit - E-EL-M0636 from Elabscience Category ELISA Kit Sensitivity 9.38 pg/mL Range 15.63—1000 pg/mL

Mouse SCF (Stem Cell Factor) CLIA Kit - E-CL-M0387 from Elabscience Category CLIA Kit Sensitivity 4.69 pg/mL Range Average Recovery (%)

KIT ligand, ELISA Kit - MBS702939 from MyBioSource Category ELISA Kit Prices $250.00, $450.00, $640.00, $2,615.00, $4,940.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse SCF/MGF is typically less than 0.78 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 pg/ml -200 pg/ml.

SCF, ELISA Kit - MBS177279 from MyBioSource Category ELISA Kit Prices $425.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 31.2pg/ml-2000pg/ml

SCF, ELISA Kit - MBS824990 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 31.2 pg/ml - 2000 pg/ml

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