Sp1

Gene Symbol Sp1
Entrez Gene 20683
Alt Symbol 1110003E12Rik, AA450830, AI845540, Sp1-1
Species Mouse
Gene Type protein-coding
Description trans-acting transcription factor 1
Other Description transcription factor Sp1
Swissprots Q64167 O89090 Q62251 O89087
Accessions CAA42721 EDL03985 O89090 AF022363 AAC08527 AF062566 AAC16484 AK003347 AK088458 BC165998 AAI65998 CF729889 CJ181598 EF200003 EF200004 EF200005 ABM98419 EF200006 EF200007 EF200008 EF200009 S79832 AAB35321 XM_011245533 XP_011243835 NM_013672 NP_038700
Function Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269|PubMed:24030830}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
Top Pathways TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer

Anti-SP1 (AB1) antibody produced in rabbit - AV37192 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: SP2/0 (<B>Cat. No. AV37192</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type SP2/0

Anti-SP1 (AB2) antibody produced in rabbit - AV37193 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: NIH3T3 (<B>Cat. No. AV37193</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 2.5 μg/mL in cell type NIH3T3

SP1 antibody - middle region (ARP37192_T100) - ARP37192_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SP1 antibody - C-terminal region (ARP37193_T100) - ARP37193_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Sp1mouse-Antibody-internal-region - AF2879a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2879a (0.3 µg/ml) staining of NIH3T3 nuclear lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SP1 antibody - 70R-32502 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1 antibody (Thr453) - 70R-36298 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1 antibody (Thr739) - 70R-32501 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1 antibody - 70R-35336 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1 antibody - 20R-1139 from Fitzgerald

Prices $290.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1 Antibody - 28-632 from ProSci

Prices $250.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Mouse SP2/0 at 1.25 ug/ml.

SP1 Antibody - 28-633 from ProSci

Prices $250.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Mouse NIH-3T3 at 2.5 ug/ml.

Goat Anti-Sp1(mouse) Antibody - EB09068 from Everest Biotech

Prices $315.00
Sizes 100µg specific antibody in 200µl
Host Goat
EB09068 (0.3µg/ml) staining of NIH3T3 nuclear lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SP1 Antibody - GWB-CD5DB1 from Genway Biotech

Prices $294.00
Sizes 100 µg
Clonality Polyclonal

Rabbit Anti-Human SP1 Polyclonal Antibody - DPABH-27974 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

SP1, Polyclonal Antibody - MBS2517612 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SP1, Polyclonal Antibody - MBS2528920 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

SP1, Polyclonal Antibody - MBS832943 from MyBioSource

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SP1, Polyclonal Antibody - MBS2519271 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Sp1, Polyclonal Antibody - MBS423399 from MyBioSource

Prices $300.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SP1, Polyclonal Antibody - MBS835055 from MyBioSource

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Sp1, Polyclonal Antibody - MBS440049 from MyBioSource

Prices $240.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

SP1 antibody - 70R-51639 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

anti-SP1 antibody - ARG63809 from Arigo Biolaboratories

ARG63809 anti-SP1 antibody WB image Western Blot: HeLa lysate (RIPA buffer, 30µg total protein per lane) stained with ARG63809 anti-SP1 antibody at 0.3 µg/ml dilution.

anti-SP1 antibody [1A5] - ARG55542 from Arigo Biolaboratories
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