Gene Symbol | Sp1 |
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Entrez Gene | 20683 |
Alt Symbol | 1110003E12Rik, AA450830, AI845540, Sp1-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | trans-acting transcription factor 1 |
Other Description | transcription factor Sp1 |
Swissprots | Q64167 O89090 Q62251 O89087 |
Accessions | CAA42721 EDL03985 O89090 AF022363 AAC08527 AF062566 AAC16484 AK003347 AK088458 BC165998 AAI65998 CF729889 CJ181598 EF200003 EF200004 EF200005 ABM98419 EF200006 EF200007 EF200008 EF200009 S79832 AAB35321 XM_011245533 XP_011243835 NM_013672 NP_038700 |
Function | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269|PubMed:24030830}. |
Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}. |
Top Pathways | TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer |
Sp1 CRISPR/Cas9 KO Plasmid (m) - sc-423094 from Santa Cruz Biotechnology
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Sp1 HDR Plasmid (m) - sc-423094-HDR from Santa Cruz Biotechnology
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Sp1 Double Nickase Plasmid (m) - sc-423094-NIC from Santa Cruz Biotechnology
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Sp1 Double Nickase Plasmid (m2) - sc-423094-NIC-2 from Santa Cruz Biotechnology
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Sp1 CRISPR Activation Plasmid (m) - sc-423094-ACT from Santa Cruz Biotechnology
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Sp1 CRISPR Activation Plasmid (m2) - sc-423094-ACT-2 from Santa Cruz Biotechnology
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Sp1 Lentiviral Activation Particles (m) - sc-423094-LAC from Santa Cruz Biotechnology
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Sp1 Lentiviral Activation Particles (m2) - sc-423094-LAC-2 from Santa Cruz Biotechnology
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Sp1 siRNA (m) - sc-29488 from Santa Cruz Biotechnology
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Sp1 shRNA Plasmid (m) - sc-29488-SH from Santa Cruz Biotechnology
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Sp1 shRNA (m) Lentiviral Particles - sc-29488-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU061231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41847 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41847 from Sigma-Aldrich
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SP1 siRNA (Mouse) - CRM3865 from Cohesion Biosciences
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SP1 - MBS8216251 from MyBioSource
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shRNA set against Mouse SP1 (NM_013672.2) - SHH415520 from Creative biogene
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Mouse SP1 siRNA - orb283341 from Biorbyt
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SP1 shRNA Plasmid (Mouse) - CHM3865 from Cohesion Biosciences
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SP1 miRNA 3'UTR clone - MiUTR1M-11107 from Creative biogene
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