| Gene Symbol |
Sp1
|
| Entrez Gene |
20683
|
| Alt Symbol |
1110003E12Rik, AA450830, AI845540, Sp1-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
trans-acting transcription factor 1
|
| Other Description |
transcription factor Sp1
|
| Swissprots |
Q64167 O89090 Q62251 O89087
|
| Accessions |
CAA42721 EDL03985 O89090 AF022363 AAC08527 AF062566 AAC16484 AK003347 AK088458 BC165998 AAI65998 CF729889 CJ181598 EF200003 EF200004 EF200005 ABM98419 EF200006 EF200007 EF200008 EF200009 S79832 AAB35321 XM_011245533 XP_011243835 NM_013672 NP_038700
|
| Function |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269|PubMed:24030830}.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
|
| Top Pathways |
TGF-beta signaling pathway, Huntington's disease, Estrogen signaling pathway, Choline metabolism in cancer, Transcriptional misregulation in cancer
|