Gene Symbol | MSX2 |
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Entrez Gene | 4488 |
Alt Symbol | CRS2, FPP, HOX8, MSH, PFM, PFM1 |
Species | Human |
Gene Type | protein-coding |
Description | msh homeobox 2 |
Other Description | homeobox protein Hox-8|homeobox protein MSX-2|msh homeo box 2|msh homeobox homolog 2 |
Swissprots | P35548 Q53XM4 D3DQN1 Q9UD60 |
Accessions | AAB42178 AAD14169 CAL40519 EAW61381 EAW61382 P35548 AL552909 BC015509 AAH15509 BT009814 AAP88816 D14970 BAA03611 D26145 D31771 BAA06549 D89377 BAA13949 DQ891600 ABM82526 DQ894795 ABM85721 S75361 AAB33867 W38629 X69295 CAA49156 NM_002449 NP_002440 |
Function | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
Subcellular Location | Nucleus. |
Top Pathways | HTLV-I infection |
Msx-2 (B-2) - sc-393986 from Santa Cruz Biotechnology
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Msx-2 (F-6) - sc-365232 from Santa Cruz Biotechnology
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Msx-2 (M-70) - sc-15396 from Santa Cruz Biotechnology
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Msx-2 (N-20) - sc-17729 from Santa Cruz Biotechnology
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Msx-2 (T-20) - sc-17731 from Santa Cruz Biotechnology
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Anti-Msx2/Hox8 antibody - ab69058 from Abcam
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Anti-Msx2/Hox8 antibody - ab70980 from Abcam
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Anti-Msx2/Hox8 antibody - ab123652 from Abcam
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Anti-Msx2/Hox8 antibody - ab176357 from Abcam
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Anti-Msx2/Hox8 antibody [1F6] - ab111246 from Abcam
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Anti-Msx2/Hox8 antibody [2E12] - ab22601 from Abcam
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Anti-Msx2/Hox8 antibody - N-terminal - ab190070 from Abcam
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Anti-MSX2 / MSH Antibody (aa1-77) - LS-C9106 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (clone GF1) - LS-C190113 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, APC) - LS-C263632 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, AP) - LS-C263631 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, Biotin) - LS-C263633 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, FITC) - LS-C263634 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, Azide-free, HRP) - LS-C263635 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (aa119-148, AP) - LS-C263637 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (C-Terminus, PE) - LS-C263636 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (aa119-148, Biotin) - LS-C263639 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (aa119-148, FITC) - LS-C263640 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (aa119-148, APC) - LS-C263638 from LifeSpan Bioscience
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Anti-MSX2 / MSH Antibody (N-Terminus) - LS-C109584 from LifeSpan Bioscience
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