Gene Symbol | MSX2 |
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Entrez Gene | 4488 |
Alt Symbol | CRS2, FPP, HOX8, MSH, PFM, PFM1 |
Species | Human |
Gene Type | protein-coding |
Description | msh homeobox 2 |
Other Description | homeobox protein Hox-8|homeobox protein MSX-2|msh homeo box 2|msh homeobox homolog 2 |
Swissprots | P35548 Q53XM4 D3DQN1 Q9UD60 |
Accessions | AAB42178 AAD14169 CAL40519 EAW61381 EAW61382 P35548 AL552909 BC015509 AAH15509 BT009814 AAP88816 D14970 BAA03611 D26145 D31771 BAA06549 D89377 BAA13949 DQ891600 ABM82526 DQ894795 ABM85721 S75361 AAB33867 W38629 X69295 CAA49156 NM_002449 NP_002440 |
Function | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
Subcellular Location | Nucleus. |
Top Pathways | HTLV-I infection |
Msx-2 CRISPR/Cas9 KO Plasmid (h) - sc-403657 from Santa Cruz Biotechnology
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Msx-2 HDR Plasmid (h) - sc-403657-HDR from Santa Cruz Biotechnology
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Msx-2 Double Nickase Plasmid (h) - sc-403657-NIC from Santa Cruz Biotechnology
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Msx-2 Double Nickase Plasmid (h2) - sc-403657-NIC-2 from Santa Cruz Biotechnology
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Msx-2 CRISPR Activation Plasmid (h) - sc-403657-ACT from Santa Cruz Biotechnology
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Msx-2 CRISPR Activation Plasmid (h2) - sc-403657-ACT-2 from Santa Cruz Biotechnology
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Msx-2 Lentiviral Activation Particles (h) - sc-403657-LAC from Santa Cruz Biotechnology
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Msx-2 Lentiviral Activation Particles (h2) - sc-403657-LAC-2 from Santa Cruz Biotechnology
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Msx-2 siRNA (h) - sc-43946 from Santa Cruz Biotechnology
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Msx-2 shRNA Plasmid (h) - sc-43946-SH from Santa Cruz Biotechnology
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Msx-2 shRNA (h) Lentiviral Particles - sc-43946-V from Santa Cruz Biotechnology
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MSX2 RNAi - H00004488-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14668 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14668 from Sigma-Aldrich
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MSX2 siRNA (Human) - CRH2980 from Cohesion Biosciences
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shRNA set against Human MSX2 (NM_002449.4) - SHH345920 from Creative biogene
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shRNA set against Human MSX2(NM_002449.4) - SHH204563 from Creative biogene
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Human MSX2 siRNA - orb263482 from Biorbyt
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MSX2 shRNA Plasmid (Human) - CHH2980 from Cohesion Biosciences
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MSX2 miRNA 3'UTR clone - MiUTR1H-06488 from Creative biogene
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