| Gene Symbol |
MSX2
|
| Entrez Gene |
4488
|
| Alt Symbol |
CRS2, FPP, HOX8, MSH, PFM, PFM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
msh homeobox 2
|
| Other Description |
homeobox protein Hox-8|homeobox protein MSX-2|msh homeo box 2|msh homeobox homolog 2
|
| Swissprots |
P35548 Q53XM4 D3DQN1 Q9UD60
|
| Accessions |
AAB42178 AAD14169 CAL40519 EAW61381 EAW61382 P35548 AL552909 BC015509 AAH15509 BT009814 AAP88816 D14970 BAA03611 D26145 D31771 BAA06549 D89377 BAA13949 DQ891600 ABM82526 DQ894795 ABM85721 S75361 AAB33867 W38629 X69295 CAA49156 NM_002449 NP_002440
|
| Function |
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
HTLV-I infection
|
![Western Blot: Msx2/Hox8 Overexpression Lysate (Adult Normal) [NBP2-04226] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Msx2/Hox8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8017_Msx2-Hox8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04226-img0001.jpg)