REST

Gene Symbol	REST
Entrez Gene	5978
Alt Symbol	NRSF, XBR
Species	Human
Gene Type	protein-coding
Description	RE1-silencing transcription factor
Other Description	RE1-silencing transcription factor variant E1a/E2/E3/E4c|RE1-silencing transcription factor variant E1a/E2/E3/E5|RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i|RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1a/E2/E4|RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j|RE1-silencing transcription factor variant E1b/E2/E3/E5|RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i|RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4|RE1-silencing transcription factor variant E1c/E2/E3/E5|RE1-silencing transcription factor variant E1c/E2g/E3/E4|neural-restrictive silencer factor|neuron restrictive silencer factor|repressor binding to the X2 box
Swissprots	Q8IWI3 Q13127 Q13134 Q12956 Q59ER1 A2RUE0 Q12957 B9EGJ0
Accessions	EAX05516 EAX05517 Q13127 AB209750 BAD92987 AF228045 AAF61710 BC017822 AAH17822 BC038985 AAH38985 BC132859 AAI32860 BC136491 AAI36492 JX896957 AFZ81807 JX896958 AFZ81808 JX896959 AFZ81809 JX896960 JX896961 JX896962 JX896963 JX896964 JX896965 JX896966 AFZ81810 JX896967 JX896968 AFZ81811 JX896969 JX896970 AFZ81812 JX896971 AFZ81813 JX896972 JX896973 JX896974 JX896975 JX896976 JX896977 JX896978 AFZ81814 JX896979 AFZ81815 JX896980 AFZ81816 JX896981 AFZ81817 JX896982 AFZ81818 JX896983 AFZ81819 JX896984 AFZ81820 JX896985 JX896986 JX896987 JX896988 JX896989 AFZ81821 JX896990 AFZ81822 JX896991 AFZ81823 JX896992 AFZ81824 JX896993 AFZ81825 KC117262 KC117263 KC117264 KC117265 KC117266 AFZ81826 U13877 AAC50114 U13879 AAC50115 U22314 AAB17211 XM_005265760 XP_005265817 XM_011534401 XP_011532703 XM_011534402 XP_011532704 NM_001193508 NP_001180437 NM_005612 NP_005603
Function	Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. {ECO:0000269|PubMed:8568247}.
Top Pathways	Huntington's disease, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RE1-silencing transcription factor (REST), Human, ELISA Kit - CSB-EL019571HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

RE1-silencing transcription factor, ELISA Kit - MBS922211 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

ChIPAb+ REST - ChIP Validated Antibody and Primer Set - 17-10456 from EMD Millipore

Human RE1-silencing transcription factor(REST) ELISA kit - CSB-EL019571HU from Cusabio Category ELISA Kit Sensitivity 7.81pg/ml Range 31.25 pg/ml-2000 pg/ml

Human RE1-silencing transcription factor (REST) ELISA Kit - EKC35342 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Human REST ELISA Kit - E032951 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human REST is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

REST ELISA Kit (Human) (OKCA00797) - OKCA00797 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 7.81 pg/mL Range 31.25 pg/mL-2,000 pg/mL

Human RE1-silencing transcription factor (REST) ELISA Kit - AE22455HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 7.81 pg/mL Range 31.25 -2000 pg/mL

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9359935 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9356655 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9356312 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9347862 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9350706 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9369269 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9358430 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9367617 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9358850 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9357323 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9365408 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9343434 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9353344 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9351666 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9354282 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9367213 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

RE1-Silencing Transcription Factor (REST), ELISA Kit - MBS9366383 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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