REST

Gene Symbol REST
Entrez Gene 5978
Alt Symbol NRSF, XBR
Species Human
Gene Type protein-coding
Description RE1-silencing transcription factor
Other Description RE1-silencing transcription factor variant E1a/E2/E3/E4c|RE1-silencing transcription factor variant E1a/E2/E3/E5|RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i|RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1a/E2/E4|RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j|RE1-silencing transcription factor variant E1b/E2/E3/E5|RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i|RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4|RE1-silencing transcription factor variant E1c/E2/E3/E5|RE1-silencing transcription factor variant E1c/E2g/E3/E4|neural-restrictive silencer factor|neuron restrictive silencer factor|repressor binding to the X2 box
Swissprots Q8IWI3 Q13127 Q13134 Q12956 Q59ER1 A2RUE0 Q12957 B9EGJ0
Accessions EAX05516 EAX05517 Q13127 AB209750 BAD92987 AF228045 AAF61710 BC017822 AAH17822 BC038985 AAH38985 BC132859 AAI32860 BC136491 AAI36492 JX896957 AFZ81807 JX896958 AFZ81808 JX896959 AFZ81809 JX896960 JX896961 JX896962 JX896963 JX896964 JX896965 JX896966 AFZ81810 JX896967 JX896968 AFZ81811 JX896969 JX896970 AFZ81812 JX896971 AFZ81813 JX896972 JX896973 JX896974 JX896975 JX896976 JX896977 JX896978 AFZ81814 JX896979 AFZ81815 JX896980 AFZ81816 JX896981 AFZ81817 JX896982 AFZ81818 JX896983 AFZ81819 JX896984 AFZ81820 JX896985 JX896986 JX896987 JX896988 JX896989 AFZ81821 JX896990 AFZ81822 JX896991 AFZ81823 JX896992 AFZ81824 JX896993 AFZ81825 KC117262 KC117263 KC117264 KC117265 KC117266 AFZ81826 U13877 AAC50114 U13879 AAC50115 U22314 AAB17211 XM_005265760 XP_005265817 XM_011534401 XP_011532703 XM_011534402 XP_011532704 NM_001193508 NP_001180437 NM_005612 NP_005603
Function Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. {ECO:0000269|PubMed:8568247}.
Top Pathways Huntington's disease, Signaling pathways regulating pluripotency of stem cells

NRSF CRISPR/Cas9 KO Plasmid (h) - sc-418578 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF HDR Plasmid (h) - sc-418578-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF Double Nickase Plasmid (h) - sc-418578-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF Double Nickase Plasmid (h2) - sc-418578-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF CRISPR Activation Plasmid (h) - sc-418578-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF CRISPR Activation Plasmid (h2) - sc-418578-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF Lentiviral Activation Particles (h) - sc-418578-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF Lentiviral Activation Particles (h2) - sc-418578-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NRSF siRNA (h) - sc-38129 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRSF shRNA Plasmid (h) - sc-38129-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRSF shRNA (h) Lentiviral Particles - sc-38129-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NRSF RNAi - H00005978-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU090231 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1343 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1343 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

REST siRNA (Human) - CRH4046 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

REST - MBS8225838 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Rest (NM_005612.4) - SHH392032 from Creative biogene

Category siRNA
Species Reactivities Human

REST shRNA Plasmid (Human) - CHH4046 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

REST miRNA 3'UTR clone - MiUTR1H-08741 from Creative biogene

Species Reactivities Human
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