| Gene Symbol |
REST
|
| Entrez Gene |
5978
|
| Alt Symbol |
NRSF, XBR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RE1-silencing transcription factor
|
| Other Description |
RE1-silencing transcription factor variant E1a/E2/E3/E4c|RE1-silencing transcription factor variant E1a/E2/E3/E5|RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i|RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1a/E2/E4|RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j|RE1-silencing transcription factor variant E1b/E2/E3/E5|RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i|RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4|RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4|RE1-silencing transcription factor variant E1c/E2/E3/E5|RE1-silencing transcription factor variant E1c/E2g/E3/E4|neural-restrictive silencer factor|neuron restrictive silencer factor|repressor binding to the X2 box
|
| Swissprots |
Q8IWI3 Q13127 Q13134 Q12956 Q59ER1 A2RUE0 Q12957 B9EGJ0
|
| Accessions |
EAX05516 EAX05517 Q13127 AB209750 BAD92987 AF228045 AAF61710 BC017822 AAH17822 BC038985 AAH38985 BC132859 AAI32860 BC136491 AAI36492 JX896957 AFZ81807 JX896958 AFZ81808 JX896959 AFZ81809 JX896960 JX896961 JX896962 JX896963 JX896964 JX896965 JX896966 AFZ81810 JX896967 JX896968 AFZ81811 JX896969 JX896970 AFZ81812 JX896971 AFZ81813 JX896972 JX896973 JX896974 JX896975 JX896976 JX896977 JX896978 AFZ81814 JX896979 AFZ81815 JX896980 AFZ81816 JX896981 AFZ81817 JX896982 AFZ81818 JX896983 AFZ81819 JX896984 AFZ81820 JX896985 JX896986 JX896987 JX896988 JX896989 AFZ81821 JX896990 AFZ81822 JX896991 AFZ81823 JX896992 AFZ81824 JX896993 AFZ81825 KC117262 KC117263 KC117264 KC117265 KC117266 AFZ81826 U13877 AAC50114 U13879 AAC50115 U22314 AAB17211 XM_005265760 XP_005265817 XM_011534401 XP_011532703 XM_011534402 XP_011532704 NM_001193508 NP_001180437 NM_005612 NP_005603
|
| Function |
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. {ECO:0000269|PubMed:8568247}.
|
| Top Pathways |
Huntington's disease, Signaling pathways regulating pluripotency of stem cells
|