| Gene Symbol |
PRDM14
|
| Entrez Gene |
63978
|
| Alt Symbol |
PFM11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PR domain containing 14
|
| Other Description |
PR domain zinc finger protein 14|PR domain-containing 14|PR domain-containing protein 14
|
| Swissprots |
Q86UX9 Q9GZV8
|
| Accessions |
EAW86962 Q9GZV8 AF319458 AAG39635 AK022595 BAB14120 BC052311 AAH52311 BF770200 CX166395 CX788380 EU446841 ABZ92370 HQ257953 ADR82707 KJ463837 AHX99430 XM_011517572 XP_011515874 NM_024504 NP_078780
|
| Function |
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250, ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17942894}.
|
| Tissue Specificity |
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). {ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.
|