| Gene Symbol |
PDE8A
|
| Entrez Gene |
5151
|
| Alt Symbol |
HsT19550
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 8A
|
| Other Description |
cAMP-specific cyclic nucleotide phosphodiesterase 8A|high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
|
| Swissprots |
Q96PC9 Q6P9H3 Q9UMC3 Q96T71 O60658 Q96PD0 Q9UMB7 B3KXE6 Q969I1 Q96PD1 H0YMZ7
|
| Accessions |
EAX01965 EAX01966 EAX01967 EAX01968 EAX01969 EAX01970 O60658 AF056490 AAC39763 AF332653 AAK57641 AF388183 AAL18610 AF388184 AAL18611 AF388185 AAL18612 AF388186 AAL18613 AF388187 AAL18614 AI767983 AK074280 AK122689 BAG53669 AK127232 BAG54458 AL109687 CAB52020 AL109778 CAB52432 AL109789 CAB52453 BC013825 BC017164 BC036190 BC037260 BC048317 AAH48317 BC060762 AAH60762 BC075822 AAH75822 XM_005254933 XP_005254990 XM_006720568 XP_006720631 XM_011521667 XP_011519969 XM_011521668 XP_011519970 NM_001243137 NP_001230066 NM_002605 NP_002596 NM_173454 NP_775656 NM_173455 NM_173456 NM_173457
|
| Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. {ECO:0000269|PubMed:18983167}.
|
| Tissue Specificity |
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
|
| Top Pathways |
Morphine addiction, Purine metabolism
|
![Western Blot: PDE8A Overexpression Lysate (Adult Normal) [NBL1-14232] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE8A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7154_PDE8A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14232-img0002.jpg)