| Gene Symbol |
NFAM1
|
| Entrez Gene |
150372
|
| Alt Symbol |
CNAIP, bK126B4.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NFAT activating protein with ITAM motif 1
|
| Other Description |
NFAT activation molecule 1|NFAT-activating protein with ITAM motif 1|calcinerin/NFAT-activating ITAM-containing protein|calcineurin/NFAT-activating ITAM-containing protein
|
| Swissprots |
Q5JZ96 Q8TEM8 Q8NET5 Q8IUY8 Q20WL2 B0QYD0
|
| Accessions |
EAW60504 EAW60505 Q8NET5 AK074094 BAB84920 AK097971 AY121370 AAM83133 AY247409 AAO91847 BC038241 AAH38241 CT841509 CAJ86439 CU013214 CAK54645 CU013502 CAK54944 XM_005261374 XP_005261431 XM_011529957 XP_011528259 XM_011529958 XP_011528260 NM_145912 NP_666017
|
| Function |
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.
|