Gene Symbol | SLC12A2 |
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Entrez Gene | 6558 |
Alt Symbol | BSC, BSC2, NKCC1, PPP1R141 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
Other Description | basolateral Na-K-Cl symporter|bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1|protein phosphatase 1, regulatory subunit 141|solute carrier family 12 (sodium/potassium/chloride transporters), member 2|solute carrier family 12 member 2 |
Swissprots | Q8N713 Q8WWH7 P55011 |
Accessions | EAW62392 EAW62393 EAW62394 P55011 AA425438 AA425619 AA843086 AB209192 BAD92429 AF439152 AAL32454 AI493213 AK025062 AV708692 AY280459 AAP33906 BC033003 BC144221 AAI44222 BC146839 AAI46840 BM978607 U30246 AAC50561 Z36839 XM_011543588 XP_011541890 NM_001046 NP_001037 NM_001256461 NP_001243390 NR_046207 |
Function | Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in many tissues. |
Top Pathways | Vibrio cholerae infection, Salivary secretion, Pancreatic secretion |
NKCC1 CRISPR/Cas9 KO Plasmid (h) - sc-416328 from Santa Cruz Biotechnology
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NKCC1 HDR Plasmid (h) - sc-416328-HDR from Santa Cruz Biotechnology
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NKCC1 Double Nickase Plasmid (h) - sc-416328-NIC from Santa Cruz Biotechnology
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NKCC1 Double Nickase Plasmid (h2) - sc-416328-NIC-2 from Santa Cruz Biotechnology
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NKCC1 CRISPR Activation Plasmid (h) - sc-416328-ACT from Santa Cruz Biotechnology
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NKCC1 CRISPR Activation Plasmid (h2) - sc-416328-ACT-2 from Santa Cruz Biotechnology
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NKCC1 Lentiviral Activation Particles (h) - sc-416328-LAC from Santa Cruz Biotechnology
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NKCC1 Lentiviral Activation Particles (h2) - sc-416328-LAC-2 from Santa Cruz Biotechnology
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NKCC1 siRNA (h2) - sc-270471 from Santa Cruz Biotechnology
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NKCC1 shRNA Plasmid (h2) - sc-270471-SH from Santa Cruz Biotechnology
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NKCC1/SLC12A2 RNAi - H00006558-R01 from Novus Biologicals
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MISSION® esiRNA - EHU070671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19404 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19404 from Sigma-Aldrich
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SLC12A2 siRNA (Human) - CRH4448 from Cohesion Biosciences
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SLC12A2 - MBS8219539 from MyBioSource
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shRNA set against Human SLC12A2 (NM_001046.2) - SHH408312 from Creative biogene
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shRNA set against Human SLC12A2(NM_001046.2) - SHR228408 from Creative biogene
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Human SLC12A2 siRNA - orb264950 from Biorbyt
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SLC12A2 shRNA Plasmid (Human) - CHH4448 from Cohesion Biosciences
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SLC12A2 miRNA 3'UTR clone - MiUTR1H-09432 from Creative biogene
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