| Gene Symbol |
NIT1
|
| Entrez Gene |
4817
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nitrilase 1
|
| Other Description |
nitrilase homolog 1
|
| Swissprots |
D3DVF4 B1AQP3 O76091 Q86X76
|
| Accessions |
AAC39901 EAW52654 EAW52655 EAW52656 EAW52657 Q86X76 AF069987 AAC39907 AI277603 AK296606 BAH12396 AK313323 BAG36128 AY893504 AAX36541 AY893938 AAX36975 BC046149 AAH46149 BI752623 BQ002524 BX416745 CB111935 CR541814 CAG46613 CR541846 CAG46644 DC302367 XM_005245214 XP_005245271 XM_005245215 XP_005245272 XM_005245216 XP_005245273 XM_006711341 XP_006711404 NM_001185092 NP_001172021 NM_001185093 NP_001172022 NM_001185094 NP_001172023 NM_005600 NP_005591
|
| Function |
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion {ECO:0000250}.
|
| Tissue Specificity |
Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9671749}.
|
![Western Blot: Nitrilase 1 Overexpression Lysate (Adult Normal) [NBL1-13648] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Nitrilase 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4294_Nitrilase%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13648-img0002.jpg)