Gene Symbol | NIT1 |
---|---|
Entrez Gene | 4817 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | nitrilase 1 |
Other Description | nitrilase homolog 1 |
Swissprots | D3DVF4 B1AQP3 O76091 Q86X76 |
Accessions | AAC39901 EAW52654 EAW52655 EAW52656 EAW52657 Q86X76 AF069987 AAC39907 AI277603 AK296606 BAH12396 AK313323 BAG36128 AY893504 AAX36541 AY893938 AAX36975 BC046149 AAH46149 BI752623 BQ002524 BX416745 CB111935 CR541814 CAG46613 CR541846 CAG46644 DC302367 XM_005245214 XP_005245271 XM_005245215 XP_005245272 XM_005245216 XP_005245273 XM_006711341 XP_006711404 NM_001185092 NP_001172021 NM_001185093 NP_001172022 NM_001185094 NP_001172023 NM_005600 NP_005591 |
Function | Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Mitochondrion {ECO:0000250}. |
Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9671749}. |