PAPD5

Gene Symbol PAPD5
Entrez Gene 64282
Alt Symbol TRF4-2
Species Human
Gene Type protein-coding
Description PAP associated domain containing 5
Other Description PAP-associated domain-containing protein 5|TUTase 3|non-canonical poly(A) RNA polymerase PAPD5|terminal uridylyltransferase 3|topoisomerase-related function protein 4-2
Swissprots Q9Y6C0 Q9NW67 B4DV38 Q8NDF8
Accessions EAW82747 EAW82748 EAW82749 EAW82750 Q8NDF8 AF089897 AAD45199 AK001141 BAA91518 AK097589 AK098806 AK223410 BAD97130 AK299294 BAG61309 AK300918 BAG62550 AL833922 CAD38778 BC035270 BC089405 AAH89405 BC143706 AAI43707 BC156329 AAI56330 BC157079 AAI57080 DN994465 FR872509 CCB84642 XM_005256092 XP_005256149 XM_005256093 XP_005256150 XM_011523275 XP_011521577 XM_011523276 XP_011521578 XM_011523277 XP_011521579 XM_011523278 XP_011521580 NM_022447 NM_001040284 NP_001035374 NM_001040285 NP_001035375
Function Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}.
Subcellular Location Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm.
Top Pathways RNA degradation

Anti-TRF4-2 antibody - ab118341 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TRF4-2 antibody (ab118341) at 0.2 µg/ml (for 1 hour) + Mouse Spleen lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-TRF4-2 antibody - ab118396 from Abcam

Host Goat
Clonality Polyclonal
Anti-TRF4-2 antibody (ab118396) at 0.3 µg/ml (incubation time: 1 hour) + Mouse Brain lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-TRF4-2 antibody - C-terminal - ab186992 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TRF4-2 antibody - C-terminal (ab186992) at 1 µg/ml + MCF7 whole cell lysate at 10 µg

Anti-TRF4-2 antibody - N-terminal - ab174129 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRF4-2 antibody - N-terminal (ab174129) at 1/100 dilution + Human placenta tissue lysate at 35 µgdeveloped using the ECL technique

Anti-PAPD5 Antibody (aa497-510) - LS-C139789 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PAPD5 antibody (0.2 ug/ml) staining of Mouse Spleen lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PAPD5 Antibody (C-Terminus) - LS-C206215 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PAPD5 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-PAPD5 Antibody (aa1-30) - LS-C158527 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PAPD5 Antibody western blot of human placenta tissue lysates (35 ug/lane). The PAPD5 Antibody detected the PAPD5 protein (arrow).

Anti-PAPD5 Antibody (aa79-90) - LS-C139795 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PAPD5 antibody (0.3 ug/ml) staining of Mouse Brain lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PAPD5 Antibody (aa1-30, APC) - LS-C265540 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30, Azide-free, HRP) - LS-C265541 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30, AP) - LS-C265539 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30, PE) - LS-C265543 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30, FITC) - LS-C284477 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30, Biotin) - LS-C284479 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 Antibody (aa1-30) - LS-C323778 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPD5 antibody produced in goat - SAB2501847 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PAPD5: <B>Cat. No. SAB2501847</B>: (0.2 μg/mL) staining of Mouse Spleen lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PAPD5 antibody produced in rabbit - HPA042968 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAPD5: <B>Cat. No. HPA042968</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

Anti-PAPD5 antibody produced in rabbit - HPA048225 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAPD5: <B>Cat. No. HPA048225</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Anti-PAPD5 antibody produced in goat - SAB2501846 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PAPD5: <B>Cat. No. SAB2501846</B>: (0.3 μg/mL) staining of Mouse Brain lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PAPD5 Antibody - C-terminal region (ARP73224_P050) - ARP73224_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PAPD5-Antibody-N-term - AP18427a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PAPD5 Antibody (N-term) (Cat. #AP18427a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).

PAPD5-aa497-510-Antibody-internal-region - AF3550a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3550a (0.2 µg/ml) staining of Mouse Spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PAPD5-aa78-90-Antibody-internal-region - AF3521a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3521a (0.3 µg/ml) staining of Human Cerebral Cortex (A), Human Frontal Cortex (B) and Mouse Brain lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PAPD5 Antibody - N-terminal region (OAAB13961) - OAAB13961 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

TRF4 2 antibody - orb73772 from Biorbyt

Prices $723.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western Blot analysis of A:U87MG whole cell lysate using TRF4 2 antibody
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