| Gene Symbol |
PAPD5
|
| Entrez Gene |
64282
|
| Alt Symbol |
TRF4-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PAP associated domain containing 5
|
| Other Description |
PAP-associated domain-containing protein 5|TUTase 3|non-canonical poly(A) RNA polymerase PAPD5|terminal uridylyltransferase 3|topoisomerase-related function protein 4-2
|
| Swissprots |
Q9Y6C0 Q9NW67 B4DV38 Q8NDF8
|
| Accessions |
EAW82747 EAW82748 EAW82749 EAW82750 Q8NDF8 AF089897 AAD45199 AK001141 BAA91518 AK097589 AK098806 AK223410 BAD97130 AK299294 BAG61309 AK300918 BAG62550 AL833922 CAD38778 BC035270 BC089405 AAH89405 BC143706 AAI43707 BC156329 AAI56330 BC157079 AAI57080 DN994465 FR872509 CCB84642 XM_005256092 XP_005256149 XM_005256093 XP_005256150 XM_011523275 XP_011521577 XM_011523276 XP_011521578 XM_011523277 XP_011521579 XM_011523278 XP_011521580 NM_022447 NM_001040284 NP_001035374 NM_001040285 NP_001035375
|
| Function |
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}.
|
| Subcellular Location |
Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm.
|
| Top Pathways |
RNA degradation
|