Gene Symbol | PTH2 |
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Entrez Gene | 113091 |
Alt Symbol | TIP39 |
Species | Human |
Gene Type | protein-coding |
Description | parathyroid hormone 2 |
Other Description | tuberoinfundibular 39 residue protein|tuberoinfundibular 39 residues|tuberoinfundibular peptide of 39 residues |
Swissprots | Q96DJ4 Q96A98 |
Accessions | EAW52480 Q96A98 AY037555 AAK68689 AY048588 AAL06597 BC093995 AAH93995 BC093997 AAH93997 XM_011526409 XP_011524711 NM_178449 NP_848544 |
Function | Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12559132, ECO:0000269|PubMed:12754053, ECO:0000269|PubMed:14988434}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. {ECO:0000269|PubMed:12098667}. |
pro-TIP39 (N-19) - sc-22688 from Santa Cruz Biotechnology
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TIP39 (S-17) - sc-325008 from Santa Cruz Biotechnology
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TIP39 (Z-24) - sc-134089 from Santa Cruz Biotechnology
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Anti-Tuberoinfundibular peptide antibody - ab28401 from Abcam
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Anti-PTH2 / Parathyroid Hormone 2 Antibody (aa62-100) - LS-C132511 from LifeSpan Bioscience
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Anti-PTH2 / Parathyroid Hormone 2 Antibody (C-Terminus) - LS-C82743 from LifeSpan Bioscience
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Parathyroid hormone 2 Antibody - NBP1-69679 from Novus Biologicals
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Anti-PTH2 antibody produced in rabbit - AV53357 from Sigma-Aldrich
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PTH2 antibody - middle region (ARP53357_P050) - ARP53357_P050 from Aviva Systems Biology
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TIP39 / PTH2 antibody - AP02242SU-N from Acris Antibodies
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TIP39 / PTH2 antibody - AP02242SU-S from Acris Antibodies
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TIP39 / PTH2 antibody - AP02243SU-N from Acris Antibodies
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TIP39 / PTH2 antibody - AP02243SU-S from Acris Antibodies
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PTH2 Antibody - 30-865 from ProSci
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PTH2 Antibody - GWB-MT040D from Genway Biotech
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Monoclonal Antibody to Parathyroid Hormone Receptor 2 (PTHR2) - MAA474Hu22 from Cloud-clone
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Polyclonal Antibody to Parathyroid Hormone Receptor 2 (PTHR2) - PAA474Hu01 from Cloud-clone
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PTH2, Polyclonal Antibody - MBS5302182 from MyBioSource
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TIP39 / PTH2 antibody - TA337573 from Acris Antibodies
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PTH2 antibody - orb325856 from Biorbyt
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Anti-PTEN-P1 Antibody A08380 - A08380 from Boster Bio
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Anti-PTH2 (aa 62-100) polyclonal antibody - CABT-BL3053 from Creative Diagnostics
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PTH2 antibody - middle region : Biotin (ARP53357_P050-Biotin) - ARP53357_P050-Biotin from Aviva Systems Biology
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PTH2 antibody - middle region : FITC (ARP53357_P050-FITC) - ARP53357_P050-FITC from Aviva Systems Biology
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PTH2 antibody - middle region : HRP (ARP53357_P050-HRP) - ARP53357_P050-HRP from Aviva Systems Biology
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