| Gene Symbol |
PTH2
|
| Entrez Gene |
113091
|
| Alt Symbol |
TIP39
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
parathyroid hormone 2
|
| Other Description |
tuberoinfundibular 39 residue protein|tuberoinfundibular 39 residues|tuberoinfundibular peptide of 39 residues
|
| Swissprots |
Q96DJ4 Q96A98
|
| Accessions |
EAW52480 Q96A98 AY037555 AAK68689 AY048588 AAL06597 BC093995 AAH93995 BC093997 AAH93997 XM_011526409 XP_011524711 NM_178449 NP_848544
|
| Function |
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12559132, ECO:0000269|PubMed:12754053, ECO:0000269|PubMed:14988434}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. {ECO:0000269|PubMed:12098667}.
|