Gene Symbol | PTH2 |
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Entrez Gene | 113091 |
Alt Symbol | TIP39 |
Species | Human |
Gene Type | protein-coding |
Description | parathyroid hormone 2 |
Other Description | tuberoinfundibular 39 residue protein|tuberoinfundibular 39 residues|tuberoinfundibular peptide of 39 residues |
Swissprots | Q96DJ4 Q96A98 |
Accessions | EAW52480 Q96A98 AY037555 AAK68689 AY048588 AAL06597 BC093995 AAH93995 BC093997 AAH93997 XM_011526409 XP_011524711 NM_178449 NP_848544 |
Function | Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12559132, ECO:0000269|PubMed:12754053, ECO:0000269|PubMed:14988434}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. {ECO:0000269|PubMed:12098667}. |
PTH2 / Parathyroid Hormone 2 Antibody Blocking Peptide - LS-E19267 from LifeSpan Bioscience
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Bit1 Peptide - GTX85497-PEP from GeneTex
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Bit1 Peptide - GTX85498-PEP from GeneTex
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PTH2 Blocking Peptide - 33R-9931 from Fitzgerald
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PTHrP Human - HOPS-011 from NeoScientific
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PTHrP N15 Human - HOPS-012 from NeoScientific
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Recombinant Parathyroid Hormone Receptor 2 (PTHR2) - RPA474Hu01 from Cloud-clone
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Recombinant Human Tuberoinfundibular peptide of 39 residues(PTH2) - CSB-YP842634HU CSB-EP842634HU CSB-BP842634HU CSB-MP842634HU from Cusabio
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TIP39 / PTH2 - TP310906 from Acris Antibodies
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Parathyroid Hormone, Recombinant Protein - MBS144660 from MyBioSource
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Parathyroid Hormone, Recombinant Protein - MBS144678 from MyBioSource
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PTH2 Peptide, Human - M34GP12675H from Creative Peptides
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Parathyroid Hormone Related Protein, Human Recombinant - 228-20968-1 from RayBiotech
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Parathyroid Hormone Related Protein N15 Labeled, Human Recombinant - 228-20969-1 from RayBiotech
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Human PTH2 / PTRH2 Protein (His Tag) - 13645-H07E from ABclonal
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