| Gene Symbol |
RBM5
|
| Entrez Gene |
10181
|
| Alt Symbol |
G15, H37, LUCA15, RMB5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 5
|
| Other Description |
RNA-binding protein 5|putative tumor suppressor LUCA15|renal carcinoma antigen NY-REN-9
|
| Swissprots |
Q9UKY8 P52756 Q9BU14 Q93021 B4DMF9 Q9UL24 B4DM16 B2RA45 Q9HDA6 B4DZ63
|
| Accessions |
AAB42216 EAW65040 EAW65041 EAW65042 P52756 AB208813 BAD92050 AB586690 BAJ19019 AF091263 AAD04159 AF103802 AAF02422 AF107493 AAF99551 AK097195 AK297249 BAG59728 AK297445 BAG59871 AK302766 BAG63975 AK314032 BAG36742 AL701303 AU129811 BC002957 BC156348 AAI56349 BC157102 AAI57103 BM985111 BQ899199 BX441555 CN293007 DA776815 DB080737 DR762951 U23946 AAA99715 XM_006712917 XP_006712980 XM_006712919 XP_006712982 XM_011533261 XP_011531563 XM_011533262 XP_011531564 XR_427245 NM_005778 NP_005769 NR_036627
|
| Function |
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18851835}.
|
| Tissue Specificity |
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
|