RBM5

Gene Symbol	RBM5
Entrez Gene	10181
Alt Symbol	G15, H37, LUCA15, RMB5
Species	Human
Gene Type	protein-coding
Description	RNA binding motif protein 5
Other Description	RNA-binding protein 5|putative tumor suppressor LUCA15|renal carcinoma antigen NY-REN-9
Swissprots	Q9UKY8 P52756 Q9BU14 Q93021 B4DMF9 Q9UL24 B4DM16 B2RA45 Q9HDA6 B4DZ63
Accessions	AAB42216 EAW65040 EAW65041 EAW65042 P52756 AB208813 BAD92050 AB586690 BAJ19019 AF091263 AAD04159 AF103802 AAF02422 AF107493 AAF99551 AK097195 AK297249 BAG59728 AK297445 BAG59871 AK302766 BAG63975 AK314032 BAG36742 AL701303 AU129811 BC002957 BC156348 AAI56349 BC157102 AAI57103 BM985111 BQ899199 BX441555 CN293007 DA776815 DB080737 DR762951 U23946 AAA99715 XM_006712917 XP_006712980 XM_006712919 XP_006712982 XM_011533261 XP_011531563 XM_011533262 XP_011531564 XR_427245 NM_005778 NP_005769 NR_036627
Function	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:18851835}.
Tissue Specificity	Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LUCA15 CRISPR/Cas9 KO Plasmid (h) - sc-407577 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 HDR Plasmid (h) - sc-407577-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 Double Nickase Plasmid (h) - sc-407577-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 Double Nickase Plasmid (h2) - sc-407577-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 CRISPR Activation Plasmid (h) - sc-407577-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 CRISPR Activation Plasmid (h2) - sc-407577-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 Lentiviral Activation Particles (h) - sc-407577-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 Lentiviral Activation Particles (h2) - sc-407577-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LUCA15 siRNA (h) - sc-106741 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LUCA15 shRNA Plasmid (h) - sc-106741-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LUCA15 shRNA (h) Lentiviral Particles - sc-106741-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RBM5 RNAi - H00010181-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RBM5 RNAi - H00010181-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU144781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18054 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18054 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04531 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04531

RBM5 siRNA (Human) - CRH6876 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RBM5 - MBS8236244 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RBM5 (NM_005778.3) - SHH390872 from Creative biogene Category siRNA Species Reactivities Human

Human RBM5 siRNA - orb267378 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RBM5 shRNA Plasmid (Human) - CHH6876 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RBM5 miRNA 3'UTR clone - MiUTR3H-08796 from Creative biogene Species Reactivities Human

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