Gene Symbol | ELP5 |
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Entrez Gene | 23587 |
Alt Symbol | C17orf81, DERP6, HSPC002, MST071, MSTP071 |
Species | Human |
Gene Type | protein-coding |
Description | elongator acetyltransferase complex subunit 5 |
Other Description | S-phase 2 protein|dermal papilla derived protein 6|elongator complex protein 5 |
Swissprots | Q8TDR9 Q7Z2T4 Q9BUB2 Q8TE02 A8K1M5 D3DTN9 Q659B6 Q9Y2Q4 |
Accessions | EAW90230 EAW90231 EAW90232 Q8TE02 AB013910 BAB87800 AF070658 AAD20964 AF087868 AAM10496 AF163262 AAQ13591 AK225983 AK289940 BAF82629 AL713741 CAH56280 BC002762 AAH02762 BE743557 BF921423 BF982004 BI916017 BM970924 BP230198 BQ648358 CA431021 CA450318 CF135215 XM_011523779 XP_011522081 NM_015362 NP_056177 NM_203413 NP_981958 NM_203414 NP_981959 NM_203415 NP_981960 |
Function | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. {ECO:0000250, ECO:0000269|PubMed:16850183}. |
Subcellular Location | Nucleus. Cytoplasm. |
Tissue Specificity | Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis. |
DERP6 CRISPR/Cas9 KO Plasmid (h) - sc-411771 from Santa Cruz Biotechnology
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DERP6 HDR Plasmid (h) - sc-411771-HDR from Santa Cruz Biotechnology
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DERP6 Double Nickase Plasmid (h) - sc-411771-NIC from Santa Cruz Biotechnology
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DERP6 Double Nickase Plasmid (h2) - sc-411771-NIC-2 from Santa Cruz Biotechnology
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DERP6 CRISPR Activation Plasmid (h) - sc-411771-ACT from Santa Cruz Biotechnology
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DERP6 CRISPR Activation Plasmid (h2) - sc-411771-ACT-2 from Santa Cruz Biotechnology
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DERP6 Lentiviral Activation Particles (h) - sc-411771-LAC from Santa Cruz Biotechnology
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DERP6 Lentiviral Activation Particles (h2) - sc-411771-LAC-2 from Santa Cruz Biotechnology
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DERP6 siRNA (h) - sc-93638 from Santa Cruz Biotechnology
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DERP6 shRNA Plasmid (h) - sc-93638-SH from Santa Cruz Biotechnology
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DERP6 shRNA (h) Lentiviral Particles - sc-93638-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4487 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4487 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08428 from Sigma-Aldrich
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ELP5 siRNA (Human) - CRH8378 from Cohesion Biosciences
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ELP5 - MBS8231454 from MyBioSource
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shRNA set against Human C17orf81 (NM_015362.3) - SHH249958 from Creative biogene
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shRNA set against Human C17orf81(NM_203413.1) - SHG117235 from Creative biogene
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shRNA set against Human C17orf81(NM_015362.3) - SHG117253 from Creative biogene
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ELP5 shRNA Plasmid (Human) - CHH8378 from Cohesion Biosciences
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ELP5 miRNA 3'UTR clone - MiUTR1H-01177 from Creative biogene
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ELP5 miRNA 3'UTR clone - MiUTR1H-01178 from Creative biogene
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ELP5 miRNA 3'UTR clone - MiUTR3H-13987 from Creative biogene
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ELP5 miRNA 3'UTR clone - MiUTR3H-13988 from Creative biogene
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