| Gene Symbol |
UFL1
|
| Entrez Gene |
23376
|
| Alt Symbol |
KIAA0776, Maxer, NLBP, RCAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UFM1-specific ligase 1
|
| Other Description |
E3 UFM1-protein ligase 1|LZAP-binding protein|Regulator of CDK5RAP3 and DDRGK1|novel LZAP-binding protein|regulator of C53/LZAP and DDRGK1
|
| Swissprots |
C0H5X5 B4DJ57 A0PJ53 Q8N765 O94874 Q9NTQ0
|
| Accessions |
EAW48506 EAW48507 EAW48508 O94874 AB018319 BAA34496 AJ420579 AK295934 BAG58719 AK307651 AK316453 BAH14824 BC015377 AAH15377 BC028608 AAH28608 BC036379 AAH36379 BP337693 NM_015323 NP_056138
|
| Function |
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:25219498}.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063}. Cytoplasm, cytosol {ECO:0000269|PubMed:20228063}.
|
| Tissue Specificity |
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. {ECO:0000269|PubMed:20018847}.
|
![Western Blot: UFL1 Overexpression Lysate (Adult Normal) [NBL1-12255] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UFL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13686_UFL1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12255-img0002.jpg)