UFL1

Gene Symbol UFL1
Entrez Gene 23376
Alt Symbol KIAA0776, Maxer, NLBP, RCAD
Species Human
Gene Type protein-coding
Description UFM1-specific ligase 1
Other Description E3 UFM1-protein ligase 1|LZAP-binding protein|Regulator of CDK5RAP3 and DDRGK1|novel LZAP-binding protein|regulator of C53/LZAP and DDRGK1
Swissprots C0H5X5 B4DJ57 A0PJ53 Q8N765 O94874 Q9NTQ0
Accessions EAW48506 EAW48507 EAW48508 O94874 AB018319 BAA34496 AJ420579 AK295934 BAG58719 AK307651 AK316453 BAH14824 BC015377 AAH15377 BC028608 AAH28608 BC036379 AAH36379 BP337693 NM_015323 NP_056138
Function E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:25219498}.
Subcellular Location Endoplasmic reticulum {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063}. Cytoplasm, cytosol {ECO:0000269|PubMed:20228063}.
Tissue Specificity Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. {ECO:0000269|PubMed:20018847}.

KIAA0776 CRISPR/Cas9 KO Plasmid (h) - sc-407950 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 HDR Plasmid (h) - sc-407950-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 Double Nickase Plasmid (h) - sc-407950-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 Double Nickase Plasmid (h2) - sc-407950-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 CRISPR Activation Plasmid (h) - sc-407950-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 CRISPR Activation Plasmid (h2) - sc-407950-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 Lentiviral Activation Particles (h) - sc-407950-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 Lentiviral Activation Particles (h2) - sc-407950-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA0776 siRNA (h) - sc-95134 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA0776 shRNA Plasmid (h) - sc-95134-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA0776 shRNA (h) Lentiviral Particles - sc-95134-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU053331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11093 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11093 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10519 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10519

UFL1 siRNA (Human) - CRH8221 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UFL1 - MBS8223130 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KIAA0776 (NM_015323.4) - SHH324615 from Creative biogene

Category siRNA
Species Reactivities Human

Human UFL1 siRNA - orb268723 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UFL1 shRNA Plasmid (Human) - CHH8221 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UFL1 miRNA 3'UTR clone - MiUTR3H-12868 from Creative biogene

Species Reactivities Human
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