UFL1

Gene Symbol UFL1
Entrez Gene 23376
Alt Symbol KIAA0776, Maxer, NLBP, RCAD
Species Human
Gene Type protein-coding
Description UFM1-specific ligase 1
Other Description E3 UFM1-protein ligase 1|LZAP-binding protein|Regulator of CDK5RAP3 and DDRGK1|novel LZAP-binding protein|regulator of C53/LZAP and DDRGK1
Swissprots C0H5X5 B4DJ57 A0PJ53 Q8N765 O94874 Q9NTQ0
Accessions EAW48506 EAW48507 EAW48508 O94874 AB018319 BAA34496 AJ420579 AK295934 BAG58719 AK307651 AK316453 BAH14824 BC015377 AAH15377 BC028608 AAH28608 BC036379 AAH36379 BP337693 NM_015323 NP_056138
Function E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:25219498}.
Subcellular Location Endoplasmic reticulum {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063}. Cytoplasm, cytosol {ECO:0000269|PubMed:20228063}.
Tissue Specificity Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. {ECO:0000269|PubMed:20018847}.

Human K0776 full length protein - ab161615 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161615 on a 12.5% SDS-PAGE stained with Coomassie Blue.

KIAA0776 / NLBP Antibody Blocking Peptide - LS-E10257 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

KIAA0776 / NLBP Antibody Blocking Peptide - LS-E19936 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human UFL1 Protein - H00023376-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

K0776-Antibody-Center-Blocking-Peptide - BP9677c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

KIAA0776 Blocking Peptide - 33R-2824 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

KIAA0776 fusion protein - Ag23404 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50
Source E. coli -derived, PET28a
Species Human

Recombinant Human E3 UFM1-protein ligase 1(UFL1) - CSB-YP012209HU CSB-EP012209HU CSB-BP012209HU CSB-MP012209HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

UFL1 Recombinant Protein Antigen - NBP1-90693PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

UFL1 Recombinant Protein Antigen - NBP1-90692PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

UFL1 Protein - NBP1-90691PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

UFL1 Peptide, Human - M34GP17037H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

E3 UFM1-protein ligase 1 (UFL1), Recombinant Protein - MBS1141179 from MyBioSource

Category Protein
Prices $1,615.00, $1,615.00, $1,840.00, $1,840.00, $2,775.00, $2,775.00, $3,235.00, $3,235.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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