| Gene Symbol |
CLEC16A
|
| Entrez Gene |
23274
|
| Alt Symbol |
Gop-1, KIAA0350
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 16, member A
|
| Other Description |
C-type lectin domain family 16 member A|protein CLEC16A
|
| Swissprots |
Q6ZTB2 O15058 Q2KHT3
|
| Accessions |
EAW85164 EAW85165 Q2KHT3 AB002348 BAA20807 AK125825 AK126771 AW072095 BC009721 BC112897 AAI12898 BX374760 DB062118 DB069341 XM_005255210 XP_005255267 XM_005255211 XP_005255268 XM_005255213 XP_005255270 XM_005255214 XP_005255271 XM_005255215 XP_005255272 XM_005255216 XP_005255273 XM_006720870 XP_006720933 XM_011522434 XP_011520736 XM_011522435 XP_011520737 XM_011522436 XP_011520738 XM_011522437 XP_011520739 XM_011522438 XP_011520740 XM_011522439 XP_011520741 XM_011522440 XP_011520742 XR_932810 NM_001243403 NP_001230332 NM_015226 NP_056041
|
| Function |
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}.
|
| Subcellular Location |
Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30}.
|
| Tissue Specificity |
Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells. {ECO:0000269|PubMed:17632545}.
|