Gene Symbol | CLEC16A |
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Entrez Gene | 23274 |
Alt Symbol | Gop-1, KIAA0350 |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 16, member A |
Other Description | C-type lectin domain family 16 member A|protein CLEC16A |
Swissprots | Q6ZTB2 O15058 Q2KHT3 |
Accessions | EAW85164 EAW85165 Q2KHT3 AB002348 BAA20807 AK125825 AK126771 AW072095 BC009721 BC112897 AAI12898 BX374760 DB062118 DB069341 XM_005255210 XP_005255267 XM_005255211 XP_005255268 XM_005255213 XP_005255270 XM_005255214 XP_005255271 XM_005255215 XP_005255272 XM_005255216 XP_005255273 XM_006720870 XP_006720933 XM_011522434 XP_011520736 XM_011522435 XP_011520737 XM_011522436 XP_011520738 XM_011522437 XP_011520739 XM_011522438 XP_011520740 XM_011522439 XP_011520741 XM_011522440 XP_011520742 XR_932810 NM_001243403 NP_001230332 NM_015226 NP_056041 |
Function | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}. |
Subcellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30}. |
Tissue Specificity | Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells. {ECO:0000269|PubMed:17632545}. |
CLEC16A / KIAA0350 Antibody Blocking Peptide - LS-E26484 from LifeSpan Bioscience
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CLEC16A / KIAA0350 Antibody Blocking Peptide - LS-E8583 from LifeSpan Bioscience
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CLEC16A / KIAA0350 Antibody Blocking Peptide - LS-E27007 from LifeSpan Bioscience
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CLEC16A-Antibody-Center-Blocking-Peptide - BP6983c from Abgent, a WuXi AppTec company
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CLEC16A (aa1040-53) blocking peptide - GTX47546-PEP from GeneTex
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CLEC16A blocking peptide - GTX88965-PEP from GeneTex
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Goat anti CLEC16A antibody Immunizing peptide - orb17222 from Biorbyt
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Goat anti CLEC16A antibody Immunizing peptide - orb17485 from Biorbyt
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CLEC16A Peptide - AC21-1321-P from Abcore
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CLEC16A Peptide - AC21-1832-P from Abcore
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CLEC16A Peptide - 42-088P from ProSci
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CLEC16A Peptide - 46-644P from ProSci
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CLEC16A fusion protein - ag19358 from Proteintech Group
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CLEC16A fusion protein - Ag24268 from Proteintech Group
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Recombinant Human Protein CLEC16A(CLEC16A) ,partial - CSB-YP640655HU CSB-EP640655HU CSB-BP640655HU CSB-MP640655HU from Cusabio
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CLEC16A, Peptide - MBS428117 from MyBioSource
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CLEC16A, Peptide - MBS426340 from MyBioSource
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CLEC16A, Peptide - MBS659121 from MyBioSource
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CLEC16A, Peptide - MBS658423 from MyBioSource
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CLEC16A Recombinant Protein Antigen - NBP1-81806PEP from Novus Biologicals
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CLEC16A Recombinant Protein Antigen - NBP1-81805PEP from Novus Biologicals
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CLEC16A-Blocking-Peptide-C-term - BP21278b from Abgent, a WuXi AppTec company
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CLEC16A Peptide, Human - M34GP03253H from Creative Peptides
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CLEC16A Recombinant Protein Antigen - NBP2-57150PEP from Novus Biologicals
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Protein CLEC16A (CLEC16A), partial, Recombinant Protein - MBS1471504 from MyBioSource
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