| Gene Symbol |
IMPACT
|
| Entrez Gene |
55364
|
| Alt Symbol |
RWDD5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
impact RWD domain protein
|
| Other Description |
Impact homolog|RWD domain containing 5|imprinted and ancient gene protein homolog|protein IMPACT
|
| Swissprots |
Q9H2X4 A8MXG0 Q49AM0 Q9P2X3
|
| Accessions |
AAG23917 AAS93618 CAV24109 CBF65942 CBU90814 EAX01184 EAX01185 EAX01186 EAX01187 EAX01188 Q9P2X3 AB026264 BAA95160 AF208694 AAG35736 AK292533 BAF85222 AK312727 BC034016 AAH34016 BC036074 AAH36074 BP384088 DQ893141 ABM84067 EU176771 ABW03572 NM_018439 NP_060909
|
| Function |
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=May be associated with polysomes. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in brain. {ECO:0000269|PubMed:11116084, ECO:0000269|PubMed:11244491}.
|