IMPACT

Gene Symbol IMPACT
Entrez Gene 55364
Alt Symbol RWDD5
Species Human
Gene Type protein-coding
Description impact RWD domain protein
Other Description Impact homolog|RWD domain containing 5|imprinted and ancient gene protein homolog|protein IMPACT
Swissprots Q9H2X4 A8MXG0 Q49AM0 Q9P2X3
Accessions AAG23917 AAS93618 CAV24109 CBF65942 CBU90814 EAX01184 EAX01185 EAX01186 EAX01187 EAX01188 Q9P2X3 AB026264 BAA95160 AF208694 AAG35736 AK292533 BAF85222 AK312727 BC034016 AAH34016 BC036074 AAH36074 BP384088 DQ893141 ABM84067 EU176771 ABW03572 NM_018439 NP_060909
Function Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=May be associated with polysomes. {ECO:0000250}.
Tissue Specificity Widely expressed. Expressed at high level in brain. {ECO:0000269|PubMed:11116084, ECO:0000269|PubMed:11244491}.

IMPACT CRISPR/Cas9 KO Plasmid (h) - sc-409286 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT HDR Plasmid (h) - sc-409286-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT Double Nickase Plasmid (h) - sc-409286-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT Double Nickase Plasmid (h2) - sc-409286-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT CRISPR Activation Plasmid (h) - sc-409286-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT CRISPR Activation Plasmid (h2) - sc-409286-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT Lentiviral Activation Particles (h) - sc-409286-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT Lentiviral Activation Particles (h2) - sc-409286-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IMPACT siRNA (h) - sc-75335 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMPACT shRNA Plasmid (h) - sc-75335-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMPACT shRNA (h) Lentiviral Particles - sc-75335-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU026251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10658 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10658 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IMPACT siRNA (Human) - CRJ0690 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IMPACT - MBS8219022 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IMPACT (NM_018439.3) - SHH319325 from Creative biogene

Category siRNA
Species Reactivities Human

Human IMPACT siRNA - orb271191 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IMPACT shRNA Plasmid (Human) - CHJ0690 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IMPACT miRNA 3'UTR clone - MiUTR4H-TG11506 from Creative biogene

Species Reactivities Human
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