| Gene Symbol |
KCNJ6
|
| Entrez Gene |
3763
|
| Alt Symbol |
BIR1, GIRK-2, GIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, KPLBS, hiGIRK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 6
|
| Other Description |
G protein-activated inward rectifier potassium channel 2|inward rectifier K(+) channel Kir3.2|inward rectifier potassium channel KIR3.2
|
| Swissprots |
Q3MJ74 P48051 Q53WW6
|
| Accessions |
AAB34738 EAX09692 P48051 AJ001894 AK313997 BAG36709 AW015013 BC101547 AAI01548 BF110130 D87327 BAA13331 DR000377 HY332424 U24660 AAC50258 XM_011529558 XP_011527860 XM_011529559 XP_011527861 NM_002240 NP_002231
|
| Function |
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
|
| Top Pathways |
GABAergic synapse, Dopaminergic synapse, Morphine addiction, Retrograde endocannabinoid signaling, Circadian entrainment
|