BCO2

Gene Symbol BCO2
Entrez Gene 83875
Alt Symbol B-DIOX-II, BCDO2
Species Human
Gene Type protein-coding
Description beta-carotene oxygenase 2
Other Description b,b-carotene-9',10'-dioxygenase|beta,beta-carotene 9',10'-dioxygenase variant 1|beta,beta-carotene 9',10'-oxygenase|beta-carotene 9',10' oxygenase|beta-carotene dioxygenase 2|carotenoid-9',10'-cleaving dioxygenase
Swissprots B4DNC3 E9PBI8 Q96JY5 Q8IUS0 E9PJJ1 Q96JC8 Q9BYV7 B0YIX5
Accessions ACA05952 EAW67189 EAW67190 EAW67191 EAW67192 EAW67193 EAW67194 Q9BYV7 AB096252 AF276432 AAK69433 AJ290393 CAC27994 AK027801 BAB55379 AK091783 BAC03747 AK297853 BAG60185 AK315300 BAG37705 BC041656 AAH41656 BC047934 BU732625 BX503569 CB162567 CD708042 NM_001037290 NP_001032367 NM_001256397 NP_001243326 NM_001256398 NP_001243327 NM_001256400 NP_001243329 NM_031938 NP_114144
Function Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269|PubMed:21106934}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:21106934}.
Tissue Specificity Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). {ECO:0000269|PubMed:15983114}.

Anti-BCO2 antibody - ab107428 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BCO2 antibody (ab107428) at 1/500 dilution + Mouse kidney tissue lysate (35ug).

Anti-BCO2 antibody - ab199297 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-BCO2 antibody (ab199297) at 1/500 dilution + human muscle lysate

Anti-BCO2 antibody - ab128346 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BCO2 antibody (ab128346) at 1 µg/ml + Mouse kidney tissue at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-BCO2 / BCDO2 Antibody (aa71-100, APC) - LS-C233092 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa71-100, AP) - LS-C233093 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa201-250) - LS-C151397 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCO2 / BCDO2 antibody Western Blot of Mouse Kidney.

Anti-BCO2 / BCDO2 Antibody (aa71-100, FITC) - LS-C233095 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa71-100, Biotin) - LS-C233094 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa71-100) - LS-C156764 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BCDO2 Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The BCDO2 antibody detected the BCDO2 protein (arrow).

Anti-BCO2 / BCDO2 Antibody (aa71-100, PE) - LS-C233097 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa391-440) - LS-C135829 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCO2 antibody LS-C135829 Western blot of HT1080 Cell lysate. Antibody concentration 1 ug/ml.

Anti-BCO2 / BCDO2 Antibody (aa71-100) - LS-C319797 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO2 / BCDO2 Antibody (aa71-100, Azide-free, HRP) - LS-C249509 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

BCO2 Antibody - NBP1-90770 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: BCO2 Antibody [NBP1-90770] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Human cell line RT-4Lane 3: Human cell line U-251MG sp

BCO2 Antibody - NBP1-90769 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: BCO2 Antibody [NBP1-90769] - Staining of human stomach, lower shows strong cytoplasmic positivity in glandular cells.

Anti-BCO2 antibody produced in rabbit - HPA040695 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BCO2: <B>Cat. No. HPA040695</B>: Immunohistochemical staining of human stomach, lower shows strong cytoplasmic positivity in glandular cells.

Anti-BCO2 antibody produced in rabbit - HPA039825 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BCO2: <B>Cat. No. HPA039825</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in renal tubules.

ANTI-BCDO2 (N-TERMINAL) antibody produced in rabbit - SAB1305703 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BCDO2 (N-term): <B>Cat. No. SAB1305703</B>: BCDO2 Antibody (N-term) western blot analysis in Mouse kidney tissue lysates (35 μg/lane).

BCO2 antibody - C-terminal region (ARP60586_P050) - ARP60586_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BCO2 Antibody - N-terminal region (OAAB01070) - OAAB01070 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

BCDO2-Antibody-N-term - AP11050a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
BCDO2 Antibody (N-term) (Cat. #AP11050a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the BCDO2 antibody detected the BCDO2 protein (arrow).
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