| Gene Symbol |
BCO2
|
| Entrez Gene |
83875
|
| Alt Symbol |
B-DIOX-II, BCDO2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beta-carotene oxygenase 2
|
| Other Description |
b,b-carotene-9',10'-dioxygenase|beta,beta-carotene 9',10'-dioxygenase variant 1|beta,beta-carotene 9',10'-oxygenase|beta-carotene 9',10' oxygenase|beta-carotene dioxygenase 2|carotenoid-9',10'-cleaving dioxygenase
|
| Swissprots |
B4DNC3 E9PBI8 Q96JY5 Q8IUS0 E9PJJ1 Q96JC8 Q9BYV7 B0YIX5
|
| Accessions |
ACA05952 EAW67189 EAW67190 EAW67191 EAW67192 EAW67193 EAW67194 Q9BYV7 AB096252 AF276432 AAK69433 AJ290393 CAC27994 AK027801 BAB55379 AK091783 BAC03747 AK297853 BAG60185 AK315300 BAG37705 BC041656 AAH41656 BC047934 BU732625 BX503569 CB162567 CD708042 NM_001037290 NP_001032367 NM_001256397 NP_001243326 NM_001256398 NP_001243327 NM_001256400 NP_001243329 NM_031938 NP_114144
|
| Function |
Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269|PubMed:21106934}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:21106934}.
|
| Tissue Specificity |
Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). {ECO:0000269|PubMed:15983114}.
|
![Western Blot: BCO2 Overexpression Lysate (Adult Normal) [NBP2-06095] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BCO2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10385_BCO2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06095-img0001.jpg)