Gene Symbol | BCO2 |
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Entrez Gene | 83875 |
Alt Symbol | B-DIOX-II, BCDO2 |
Species | Human |
Gene Type | protein-coding |
Description | beta-carotene oxygenase 2 |
Other Description | b,b-carotene-9',10'-dioxygenase|beta,beta-carotene 9',10'-dioxygenase variant 1|beta,beta-carotene 9',10'-oxygenase|beta-carotene 9',10' oxygenase|beta-carotene dioxygenase 2|carotenoid-9',10'-cleaving dioxygenase |
Swissprots | B4DNC3 E9PBI8 Q96JY5 Q8IUS0 E9PJJ1 Q96JC8 Q9BYV7 B0YIX5 |
Accessions | ACA05952 EAW67189 EAW67190 EAW67191 EAW67192 EAW67193 EAW67194 Q9BYV7 AB096252 AF276432 AAK69433 AJ290393 CAC27994 AK027801 BAB55379 AK091783 BAC03747 AK297853 BAG60185 AK315300 BAG37705 BC041656 AAH41656 BC047934 BU732625 BX503569 CB162567 CD708042 NM_001037290 NP_001032367 NM_001256397 NP_001243326 NM_001256398 NP_001243327 NM_001256400 NP_001243329 NM_031938 NP_114144 |
Function | Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269|PubMed:21106934}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:21106934}. |
Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). {ECO:0000269|PubMed:15983114}. |
Human BCO2 / BCDO2 ELISA Kit (Sandwich ELISA) - LS-F10918 from LifeSpan Bioscience
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Beta,beta-carotene 9',10'-oxygenase, BCO2, Human, ELISA Kit - E10866h from ARP American Research Products
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beta, beta-carotene 9', 10'-oxygenase, BCO2, ELISA Kit - MBS9306633 from MyBioSource
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Mouse BCO2 / BCDO2 ELISA Kit (Custom ELISA) - LS-F15957 from LifeSpan Bioscience
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Beta,beta-carotene 9',10'-oxygenase, ELISA Kit - MBS288104 from MyBioSource
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Human Beta,beta-carotene 9',10'-oxygenase ELISA Kit - abx250481 from Abbexa
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Human Beta,beta-carotene 9',10'-oxygenase ELISA Kit - EKE52714 from Biomatik
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BCO2 - EKH2448 from Nordic BioSite
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BCO2 ELISA Kit (Human) (OKEH02120) - OKEH02120 from Aviva Systems Biology
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Human BCO2 ELISA Kit - E004721 from Biobool
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Human Beta,beta-carotene 9',10'-oxygenase ELISA Kit - EK2713 from Signalway Antibody
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Beta, beta-carotene 9', 10'-oxygenase, ELISA Kit - MBS9426550 from MyBioSource
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Beta,beta-carotene 9',10'-oxygenase, ELISA Kit - MBS765460 from MyBioSource
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Beta,beta-carotene 9',10'-oxygenase, ELISA Kit - MBS2886831 from MyBioSource
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Human BCO2 / BCDO2 ELISA Kit (Sandwich ELISA) - LS-F34182 from LifeSpan Bioscience
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